Prevalence and Clinical Characteristics including Patterns of Antihypertensive Drug Administration of the Different Home Blood Pressure Phenotypes in Treated Hypertensive Patients
Table 2
The regimen of prescribed antihypertensive drugs of home blood pressure phenotypes by using a home blood pressure target of <135/85 mmHg.
Frequency of drug administration (times per day) N (%)
<0.001
1
505 (64.41)
91 (51.12)
51 (49.04)
163 (47.94)
810 (57.61)
2
240 (30.61)
71 (39.89)
41 (39.42)
137 (40.29)
489 (34.78)
3
33 (4.21)
9 (5.06)
8 (7.69)
25 (7.35)
75 (5.33)
4
6 (0.77)
7 (3.93)
4 (3.85)
15 (4.41)
32 (2.28)
Timing of antihypertensive drug administration N (%)
<0.001
Only morning administration
405 (51.66)
59 (33.15)
39 (37.50)
98 (28.82)
601 (42.75)
Only evening administration
103 (13.14)
32 (17.98)
13 (12.50)
65 (19.12)
213 (15.15)
Both morning and evening administration
276 (35.20)
87 (48.88)
52 (50.00)
177 (52.06)
592 (42.11)
Evening drug administration N (%)
379 (48.34)
119 (66.85)†
65 (62.50)†
242 (71.18)†
805 (57.25)
<0.001
Proportion of TIS (evening) to TIS (24 hours)‡ (%)
27.44 ± 35.18
40.84 ± 36.34†
34.69 ± 33.84
43.34 ± 36.07†
33.52 ± 36.12
<0.001
Use of at least 1 long-acting antihypertensive drug administration in each time N (%)
<0.001
Only morning administration of short-acting drugs
57 (7.27)
8 (4.49)
8 (7.69)
13 (3.82)
86 (6.12)
Only morning administration of long-acting drugs
348 (44.39)
51 (28.65)
31 (29.81)
85 (25.00)
515 (36.63)
Only evening administration of short-acting drugs
26 (3.32)
13 (7.30)
2 (1.92)
13 (3.82)
54 (3.84)
Only evening administration of long-acting drugs
77 (9.82)
19 (10.67)
11 (10.58)
52 (15.29)
159 (11.31)
Both morning and evening administration of short-acting drugs
18 (2.30)
2 (1.12)
2 (1.92)
5 (1.47)
27 (1.92)
Both morning and evening administration of long-acting drugs
258 (32.91)
85 (47.75)
50 (48.08)
172 (50.59)
565 (40.18)
TIS, total antihypertensive therapeutic intensity score. value for comparing parameters of all home blood pressure phenotypes. † value <0.05 for comparing to controlled hypertension. ‡calculated by the following formula: .
