Serum Fibroblast Growth Factor 21 Level Is Associated with Aortic Stiffness in Patients on Maintenance Hemodialysis

Table 3

Correlations between central pulse wave velocity and clinical variables and multivariable stepwise linear regression analysis of cfPWV.

Variables	Carotid-femoral pulse wave velocity (m/s)
	Simple linear regression		Multivariable linear regression
	r	value	β	95% confidence interval	value
Female	−0.113	0.200	—	—	—
Diabetes mellitus	0.378	<0.001	1.974	0.918–3.031	0.001
Hypertension	0.128	0.145	—	—	—
Age (years)	0.194	0.027	—	—	—
Log-HD duration (months)	−0.060	0.494	—	—	—
Body weight (kg)	0.162	0.066	—	—	—
Body mass index (kg/m^2)	0.133	0.131	—	—	—
Systolic blood pressure (mmHg)	0.186	0.034	—	—	—
Diastolic blood pressure (mmHg)	−0.004	0.966	—	—	—
Mean arterial pressure (mmHg)	0.088	0.320		—	—
Pulse pressure (mmHg)	0.272	0.002		—	—
Total cholesterol (mg/dL)	−0.039	0.663	—	—	—
Log-triglyceride (mg/dL)	0.087	0.328	—	—	—
Log-fasting plasma glucose (mg/dL)	0.110	0.213	—	—	—
Total calcium (mg/dL)	0.116	0.189	—	—	—
Phosphorus (mg/dL)	0.056	0.529	—	—	—
Log-iPTH (pg/mL)	−0.153	0.082	—	—	—
Log-CRP (mg/dL)	0.242	0.006	0.978	0.030–1.927	0.037
Log-FGF-21 (pg/mL)	0.335	<0.001	3.245	1.593–4.987	<0.001
Kt/V (gotch)	−0.070	0.435	—	—	—

The data of HD duration, triglyceride, fasting plasma glucose, iPTH, CRP, and FGF-21 levels showed skewed distribution and therefore were log-transformed before analysis. Analysis of data was performed using the simple linear regression analysis or multivariate stepwise linear regression analysis (adopted factors: diabetes mellitus, age, systolic blood pressure, pulse pressure, log-CRP, and log-FGF-21). HD, hemodialysis; iPTH, intact parathyroid hormone; CRP, C-reactive protein; FGF-21, fibroblast growth factor 21; Kt/V, fractional clearance index for urea; β, unstandardized regression coefficient. was considered statistically significant.