Research Article
APOE Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China
Table 2
Frequencies of APOE rs429358, rs7412, and MTHFR rs1801133 genotypes and alleles in hypertensive patients and controls.
| | | Genotype/allele | Hypertensive patients (n = 2,850) | Controls (n = 2,034) | χ 2 | value |
| | APOE rs429358 | | | | | | | | T/T | 2320 (81.40%) | 1633 (80.29%) | 0.985 | 0.609 | | | T/C | 506 (17.75%) | 382 (18.78%) | | | C/C | 24 (0.84%) | 19 (0.93%) | | | T | 5146 (90.28%) | 3648 (89.68%) | 0.968 | 0.338 | | | C | 554 (9.72%) | 420 (10.32%) | | | HWE (χ2, ) | χ 2 = 0.389, | χ 2 = 0.412, |
| | APOE rs7412 | | | | | | | | C/C | 2464 (86.46%) | 1758 (86.43%) | 4.391 | 0.111 | | | C/T | 365 (12.81%) | 270 (13.27%) | | | T/T | 21 (0.74%) | 6 (0.29%) | | | C | 5293 (92.86%) | 3786 (93.07%) | 0.157 | 0.718 | | | T | 407 (7.14%) | 282 (6.93%) | | | HWE (χ2, ) | χ 2 = 3.340, P = 0.068 | χ 2 = 1.683, |
| | MTHFR rs1801133 | | | | | | | | C/C | 1573 (55.19%) | 1145 (56.29%) | 0.615 | 0.736 | | | C/T | 1091 (38.28%) | 762 (37.46%) | | | T/T | 186 (6.53%) | 127 (6.24%) | | | C | 4237 (74.33%) | 3052 (75.02%) | 0.599 | 0.450 | | | T | 1463 (25.67%) | 1016 (24.98%) | | | HWE (χ2, ) | χ 2 = 0.030, | χ 2 = 0.0002, |
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HWE, Hardy Weinberg equilibrium.
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