APOE Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China

Table 3

Clinical characteristics of subjects stratified by APOE rs429358 and rs7412 genotypes and ɛ2, ɛ3, and ɛ4 alleles.

Clinical characteristics

rs429358

rs7412

APOE alleles

T/T (n = 3,953)

T/C (n = 888)

C/C (n = 43)

T/C+ C/C (n = 931)

C/C (n = 4,222)

C/T (n = 635)

T/T (n = 27)

C/T+ T/T (n = 662)

ɛ2 (n = 587)

ɛ3 (n = 3,366)

ɛ4 (n = 856)

values

Age, years

66.92 ± 12.39

65.80 ± 12.20

64.37 ± 12.04

65.73 ± 12.19

66.67 ± 12.27

66.72 ± 12.83

68.67 ± 14.47

66.80 ± 12.89

67.11 ± 12.58

66.88 ± 12.35

65.85 ± 11.91

0.067

Gender

Male, n(%)

2547 (64.43)

583 (65.65)

30 (69.77)

613 (65.84)

2738 (64.85)

400 (62.99)

22 (81.48)

422 (63.75)

367 (62.52)

2180 (64.77)

558 (65.19)

0.529

Female, n(%)

1406 (35.57)

305 (34.35)

13 (30.23)

318 (34.16)

1484 (35.15)

235 (37.01)

5 (18.52)

240 (36.25)

220 (37.48)

1186 (35.23)

298 (34.81)

History of smoking, n(%)

1101 (27.85)

247 (27.82)

13 (30.23)

260 (27.93)

1198 (28.38)

153 (24.09)

10 (37.04)

163 (24.62)

146 (24.87)

955 (28.37)

243 (28.39)

0.209

History of alcoholism, n(%)

256 (6.48)

52 (5.86)

1 (2.33)

53 (5.69)

267 (6.32)

40 (6.30)

2 (7.41)

42 (6.34)

39 (6.64)

217 (6.45)

50 (5.84)

0.771

SBP, mmHg

142.09 ± 26.98

140.61 ± 27.38

138.23 ± 22.86

140.50 ± 27.18

141.81 ± 26.79

141.54 ± 28.53

142.96 ± 27.36

141.60 ± 28.47

141.53 ± 28.44

142.18 ± 26.72

140.36 ± 27.05

0.204

DBP, mmHg

82.69 ± 15.58

81.90 ± 15.85

83.51 ± 17.02

81.98 ± 15.90

82.62 ± 15.54

82.08 ± 16.35

83.81 ± 14.60

82.15 ± 16.27

82.18 ± 16.40

82.78 ± 15.43

81.98 ± 15.95

0.337

Hcy, μmol/L

16.64 ± 8.08

16.33 ± 7.57

15.27 ± 5.16

16.28 ± 7.48

16.59 ± 7.87

16.44 ± 8.72

17.56 ± 4.88

16.48 ± 8.60

16.31 ± 7.62

16.70 ± 8.16

16.15 ± 6.58

0.133

TG, mmol/L

1.71 ± 1.60

1.99 ± 2.18

2.09 ± 2.12

2.00 ± 2.18

1.76 ± 1.73

1.74 ± 1.64

2.74 ± 2.36

1.79 ± 1.69

1.75 ± 1.70

1.71 ± 1.58

2.00 ± 2.22

<0.001

TC, mmol/L

4.85 ± 1.40

5.01 ± 1.44

5.20 ± 1.38

5.02 ± 1.44

4.93 ± 1.41

4.54 ± 1.35

5.24 ± 2.07

4.57 ± 1.39

4.57 ± 1.43

4.90 ± 1.39

5.06 ± 1.46

<0.001

HDL-C, mmol/L

1.28 ± 0.39

1.21 ± 0.39

1.23 ± 0.32

1.21 ± 0.38

1.26 ± 0.39

1.28 ± 0.39

1.27 ± 0.42

1.28 ± 0.39

1.29 ± 0.39

1.28 ± 0.40

1.21 ± 0.38

<0.001

LDL-C, mmol/L

2.69 ± 0.97

2.88 ± 1.01

3.01 ± 1.02

2.88 ± 1.01

2.78 ± 0.99

2.38 ± 0.89

2.11 ± 0.79

2.37 ± 0.89

2.35 ± 0.90

2.75 ± 0.97

2.92 ± 1.03

<0.001

Apo-A1, g/L

1.12 ± 0.33

1.06 ± 0.33

1.07 ± 0.28

1.06 ± 0.33

1.10 ± 0.33

1.12 ± 0.33

1.12 ± 0.26

1.12 ± 0.32

1.13 ± 0.32

1.11 ± 0.33

1.06 ± 0.33

<0.001

Apo-B, g/L

0.84 ± 0.28

0.89 ± 0.31

0.94 ± 0.34

0.89 ± 0.31

0.86 ± 0.29

0.76 ± 0.27

0.67 ± 0.25

0.76 ± 0.27

0.75 ± 0.27

0.85 ± 0.28

0.90 ± 0.31

<0.001

Compared to the patients with the wild-type genotype, and for rs429358 and rs7412.