Research Article
APOE Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China
Table 5
Association of APOE rs429358, rs7412, and MTHFR rs1801133 polymorphisms with hypertension.
| | SNP | Model | Genotype | Hypertension (n = 2,850) | Control (n = 2,034) | Univariate OR (95% CI) | values | Multivariate OR (95% CI) | values |
| | APOE rs429358 | | | | | | | | | | | Co-dominant | T/T | 2320 (81.40%) | 1633 (80.29%) | 1.000 (reference) | | | | | | | T/C | 506 (17.75%) | 382 (18.78%) | 0.932 (0.805–1.080) | 0.351 | 0.929 (0.801–1.078) | 0.333 | | | | C/C | 24 (0.84%) | 19 (0.93%) | 0.889 (0.485–1.628) | 0.703 | 0.901 (0.490–1.657) | 0.738 | | | Dominant | T/T | 2320 (81.40%) | 1633 (80.29%) | | | | | | | | T/C + C/C | 530 (18.60%) | 401 (19.71%) | 0.930 (0.805–1.075) | 0.327 | 0.928 (0.802–1.074) | 0.316 | | | Recessive | T/T + T/C | 2826 (99.16%) | 2015 (99.07%) | | | | | | | | C/C | 24 (0.84%) | 19 (0.93%) | 0.901 (0.492–1.649) | 0.734 | 0.918 (0.500–1.689) | 0.784 |
| | APOE rs7412 | | | | | | | | | | | Co-dominant | C/C | 2464 (86.46%) | 1758 (86.43%) | 1.000 (reference) | | | | | | | C/T | 365 (12.81%) | 270 (13.27%) | 0.965 (0.815–1.142) | 0.675 | 0.950 (0.802–1.127) | 0.559 | | | | T/T | 21 (0.74%) | 6 (0.29%) | 2.497 (1.006–6.200) | 0.049 | 2.682 (1.072–6.710) | 0.035 | | | Dominant | C/C | 2464 (86.46%) | 1758 (86.43%) | 1.000 (reference) | | | | | | | C/T + T/T | 386 (13.54%) | 276 (13.57%) | 0.998 (0.845–1.178) | 0.980 | 0.987 (0.834–1.167) | 0.874 | | | Recessive | C/C + C/T | 2829 (99.26%) | 2028 (99.71%) | 1.000 (reference) | | | | | | | T/T | 21 (0.74%) | 6 (0.29%) | 2.509 (1.011–6.227) | 0.047 | 2.689 (1.075–6.729) | 0.034 |
| | APOE allele | | | | | | | | | | | | ɛ2 carriera | 341 (11.96%) | 246 (12.09%) | 0.989 (0.830–1.178) | 0.901 | 0.976 (0.818–1.164) | 0.783 | | | | ɛ4 carrierb | 485 (17.02%) | 371 (18.24%) | 0.920 (0.793–1.068) | 0.275 | 0.917 (0.789–1.066) | 0.260 |
| | MTHFR rs1801133 | | | | | | | | | | | Co-dominant | C/C | 1573 (55.19%) | 1145 (56.29%) | 1.000 (reference) | | | | | | | C/T | 1091 (38.28%) | 762 (37.46%) | 1.042 (0.924–1.175) | 0.499 | 1.048 (0.929–1.183) | 0.444 | | | | T/T | 186 (6.53%) | 127 (6.24%) | 1.066 (0.840–1.353) | 0.598 | 1.077 (0.847–1.369) | 0.545 | | | Dominant | C/C | 1573 (55.19%) | 1145 (56.29%) | 1.000 (reference) | | | | | | | C/T + T/T | 1277 (44.81%) | 889 (43.71%) | 1.046 (0.932–1.173) | 0.446 | 1.052 (0.938–1.181) | 0.386 | | | Recessive | C/C + C/T | 2664 (93.47%) | 1907 (93.76%) | 1.000 (reference) | | | | | | | T/T | 186 (6.53%) | 127 (6.24%) | 1.048 (0.830–1.324) | 0.691 | 1.060 (0.837–1.341) | 0.630 |
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a ɛ2/ɛ2 plus ɛ2/ɛ3, reference genotype: ɛ3/ɛ3 plus ɛ3/ɛ4 plus ɛ4/ɛ4. bɛ3/ɛ4 plus ɛ4/ɛ4, reference genotype: ɛ2/ɛ2 plus ɛ2/ɛ3 plus ɛ3/ɛ3.
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