Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents

Table 4

Commonly used oil, emulsifiers, coemulsifiers, and cosolvents in LBDDS.

Brand name	Chemical definition	HLB value	Suppliers/manufacturer	Excipients
Tween 20 (T20)	PEG-20 sorbitan monolaurate	16.7	Atlas/ICI	Emulsifier
Tween 60 (T60)	Polysorbate 60	14	Atlas/ICI	Emulsifier
Tween 65 (T65)	PEG-20 sorbitan tristearate	11	Atlas/ICI	Emulsifier
Tween 80 (T80)	PEG-20 sorbitan monooleate	15	Atlas/ICI	Coemulsifier
Span 20 (S20)	Sorbitan monolaurate	8.6	Atlas/ICI	Emulsifier
Span 60 (S60)	Sorbitan monostearate	4.7	Atlas/ICI	Coemulsifier
Span80 (S80)	Sorbitan monooleate	4.3	Atlas/ICI	Coemulsifier
Brij-30	PEG-4 lauryl ether	9.7	Atlas/ICI	Emulsifier
Arlasolve DMI	Di-methyl isosorbide	—	Atlas/ICI	Coemulsifier
Capmul MCM-C8	Glyceryl caprylate	5-6	ABITEC	Emulsifier
Lecithin	L-a-Phosphatidylcholine	4–9	Alfa Aesar	Emulsifier
Cerex ELS 250	PEG-25 hydrogenated castor oil	11	Auschem SpA	Emulsifier
Akoline MCM	Caprylic/capric glycerides	5-6	Aarhuskarlshamn	Coemulsifier
Cremophor EL; Cremophor ELP	PEG-35 castor oil	12–14	BASF	Emulsifier
Cremophor RH40	PEG-35 hydrogenated castor oil	13	BASF	Emulsifier
Pluronic L44	Block copolymer of ethylene oxide and propylene oxide	12–18	BASF	Coemulsifier
Lutrol F 68	Polaxomer 188	29	BASF	Coemulsifier
Cremophor RH40	Polyoxyl-40-hydrogenated castor oil	13	BASF	Emulsifier
SLS	Sodium lauryl sulfate	40	Canadian Alcolac	Coemulsifier
Carbitol	Diethylene glycol monoethyl ether	—	Dow Chemicals	Coemulsifier
TPGS	Tocophersolan, D-α-tocopheryl PEG-1000 succinate	13	Eastman	Emulsifier
Labrafil M 2125 CS	PEG-6 corn oil	4	Gattefosse	Emulsifier
Labrafil M1944CS	PEG-6 apricot kernel oil	4	Gattefosse	Emulsifier
Labrasol	PEG-8 caprylic/capric glycerides	14	Gattefosse	Emulsifier
Labrafac CM 10	PEG-8 caprylic/capric glycerides	>10	Gattefosse	Emulsifier
Labrafil WL 2609 BS	PEG-8 corn oil	6-7	Gattefosse	Emulsifier
Peceol	Glyceryl monooleate	3-4	Gattefosse	Emulsifier
Plurol oleique CC 497	Polyglyceryl-6 dioleate	6	Gattefosse	Coemulsifier
Caprol® 6G20			Abitec CoCalgene
Hodag PGO-62
Lauroglycol 90	Propylene glycol monolaurate	5	Gattefosse	Coemulsifier
Lauroglycol FCC	Propylene glycol monolaurate	4	Gattefosse	Coemulsifier
Transcutol P	Diethylene glycol mono ethyl ether	—	Gattefosse	Coemulsifier
Labrafil 1944	PEG-6 apricot kernel oil	4	Gattefosse	Coemulsifier
HCO-40	Polyoxyethylene hydrogenated castor oil 40	13	Nikkol	Emulsifier
HCO-60	PEG-60 hydrogenated castor oil	14	Nikkol	Coemulsifier
Emulphor El-620	Ethoxylated castor oil	12–15	Rhodia	Emulsifier