Review Article
Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents
Table 4
Commonly used oil, emulsifiers, coemulsifiers, and cosolvents in LBDDS.
| Brand name | Chemical definition | HLB value | Suppliers/manufacturer | Excipients |
| Tween 20 (T20) | PEG-20 sorbitan monolaurate | 16.7 | Atlas/ICI | Emulsifier | Tween 60 (T60) | Polysorbate 60 | 14 | Atlas/ICI | Emulsifier | Tween 65 (T65) | PEG-20 sorbitan tristearate | 11 | Atlas/ICI | Emulsifier | Tween 80 (T80) | PEG-20 sorbitan monooleate | 15 | Atlas/ICI | Coemulsifier | Span 20 (S20) | Sorbitan monolaurate | 8.6 | Atlas/ICI | Emulsifier | Span 60 (S60) | Sorbitan monostearate | 4.7 | Atlas/ICI | Coemulsifier | Span80 (S80) | Sorbitan monooleate | 4.3 | Atlas/ICI | Coemulsifier | Brij-30 | PEG-4 lauryl ether | 9.7 | Atlas/ICI | Emulsifier | Arlasolve DMI | Di-methyl isosorbide | — | Atlas/ICI | Coemulsifier | Capmul MCM-C8 | Glyceryl caprylate | 5-6 | ABITEC | Emulsifier | Lecithin | L-a-Phosphatidylcholine | 4–9 | Alfa Aesar | Emulsifier | Cerex ELS 250 | PEG-25 hydrogenated castor oil | 11 | Auschem SpA | Emulsifier | Akoline MCM | Caprylic/capric glycerides | 5-6 | Aarhuskarlshamn | Coemulsifier | Cremophor EL Cremophor ELP | PEG-35 castor oil | 12–14 | BASF | Emulsifier | Cremophor RH40 | PEG-35 hydrogenated castor oil | 13 | BASF | Emulsifier | Pluronic L44 | Block copolymer of ethylene oxide and propylene oxide | 12–18 | BASF | Coemulsifier | Lutrol F 68 | Polaxomer 188 | 29 | BASF | Coemulsifier | Cremophor RH40 | Polyoxyl-40-hydrogenated castor oil | 13 | BASF | Emulsifier | SLS | Sodium lauryl sulfate | 40 | Canadian Alcolac | Coemulsifier | Carbitol | Diethylene glycol monoethyl ether | — | Dow Chemicals | Coemulsifier | TPGS | Tocophersolan, D-α-tocopheryl PEG-1000 succinate | 13 | Eastman | Emulsifier | Labrafil M 2125 CS | PEG-6 corn oil | 4 | Gattefosse | Emulsifier | Labrafil M1944CS | PEG-6 apricot kernel oil | 4 | Gattefosse | Emulsifier | Labrasol | PEG-8 caprylic/capric glycerides | 14 | Gattefosse | Emulsifier | Labrafac CM 10 | PEG-8 caprylic/capric glycerides | >10 | Gattefosse | Emulsifier | Labrafil WL 2609 BS | PEG-8 corn oil | 6-7 | Gattefosse | Emulsifier | Peceol | Glyceryl monooleate | 3-4 | Gattefosse | Emulsifier | Plurol oleique CC 497 | Polyglyceryl-6 dioleate | 6 | Gattefosse | Coemulsifier | Caprol® 6G20 | Abitec CoCalgene | Hodag PGO-62 | Lauroglycol 90 | Propylene glycol monolaurate | 5 | Gattefosse | Coemulsifier | Lauroglycol FCC | Propylene glycol monolaurate | 4 | Gattefosse | Coemulsifier | Transcutol P | Diethylene glycol mono ethyl ether | — | Gattefosse | Coemulsifier | Labrafil 1944 | PEG-6 apricot kernel oil | 4 | Gattefosse | Coemulsifier | HCO-40 | Polyoxyethylene hydrogenated castor oil 40 | 13 | Nikkol | Emulsifier | HCO-60 | PEG-60 hydrogenated castor oil | 14 | Nikkol | Coemulsifier | Emulphor El-620 | Ethoxylated castor oil | 12–15 | Rhodia | Emulsifier |
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