Research Article
Association of Antihypertensive Drug-Related Gene Polymorphisms with Stroke in the Chinese Hypertensive Population
Table 1
Demographic characteristics and associated risk factors of patients with stroke and healthy controls.
| | Variables | Categories | Controls | Stroke patients | |
| | Sex | Male | 11496 (39.9) | 406 (49.8) | <0.001 | | Female | 17349 (60.1) | 410 (50.2) |
| | Age (y) | | 64.63 ± 9.89 | 67.20 ± 8.60 | <0.001 |
| | BMI (kg/m2) | | 23.88 ± 3.19 | 23.36 ± 3.10 | <0.001 |
| | Type of usual residence | Country | 27256 (94.5) | 769 (94.2) | 0.757 | | City | 1589 (5.5) | 47 (5.8) |
| | Marital status | Unmarried | 583 (2.0) | 16 (2.0) | 0.409 | | Married | 25352 (87.9) | 706 (86.5) | | Divorced or widowed | 2910 (10.1) | 94 (11.5) |
| | Educational background | Primary school and below | 15573 (54.0) | 491 (60.2) | 0.002 | | Junior high school | 11234 (38.9) | 273 (33.4) | | High school and above | 2038 (7.1) | 52 (6.4) |
| | Control of SBP | No | 16490 (57.2) | 488 (59.8) | 0.133 | | Yes | 12355 (42.8) | 328 (40.2) |
| | Control of DBP | No | 11695 (40.5) | 308 (37.7) | 0.108 | | Yes | 17150 (59.5) | 508 (62.3) |
| | Diabetes | No | 23664 (82.0) | 654 (80.1) | 0.166 | | Yes | 5181 (18.0) | 162 (19.9) |
| | Coronary heart disease | No | 23354 (81.0) | 527 (64.6) | <0.001 | | Yes | 5491 (19.0) | 289 (35.4) |
| | COPD | No | 28494 (98.8) | 815 (99.9) | 0.004 | | Yes | 351 (1.2) | 1 (0.1) |
| | Tumor | No | 28557 (99.0) | 814 (99.8) | 0.031 | | Yes | 288 (1.0) | 2 (0.2) |
| | Family history of hypertension | No | 25416 (88.1) | 692 (84.8) | 0.004 | | Yes | 3429 (11.9) | 124 (15.2) |
| | Family history of stroke | No | 28494 (98.8) | 796 (97.5) | 0.002 | | Yes | 351 (1.2) | 20 (2.5) |
| | Family history of diabetes | No | 28399 (98.5) | 802 (98.3) | 0.699 | | Yes | 446 (1.5) | 14 (1.7) |
| | ACEIs | No | 22144 (76.8) | 531 (65.1) | <0.001 | | Yes | 6701 (23.2) | 285 (34.9) |
| | ARBs | No | 27532 (95.4) | 768 (94.1) | 0.073 | | Yes | 1313 (4.6) | 48 (5.9) |
| | BBs | No | 27617 (95.7) | 785 (96.2) | 0.522 | | Yes | 1228 (4.3) | 31 (3.8) |
| | Diuretics | No | 23762 (82.4) | 650 (79.7) | 0.045 | | Yes | 5083 (17.6) | 166 (20.3) |
| | CCBs | No | 9474 (32.8) | 180 (22.1) | <0.001 | | Yes | 19371 (67.2) | 636 (77.9) |
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COPD, chronic obstructive pulmonary disease; ACEI, angiotensin-converting enzyme inhibitor; ARBs, angiotensin-II receptor antagonists; BBs, beta receptor blockers; CCBs, calcium channel blockers.
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