Research Article
Association of Antihypertensive Drug-Related Gene Polymorphisms with Stroke in the Chinese Hypertensive Population
Table 2
Genotypes and allele frequency distribution in hypertensive population.
| | Gene loci | Genotype (%) | Allele (%) | | WW | WM | MM | W | M |
| | ADRB1 (1165G > C) | 1971 (6.6) | 11218 (37.8) | 16472 (55.5) | 15160 (25.6) | 44162 (74.4) | | CYP2D6 10 | 6255 (21.1) | 12855 (43.3) | 10551 (35.6) | 25365 (42.8) | 33957 (57.2) | | CYP2C9 3 | 27204 (91.7) | 2387 (8.0) | 70 (0.2) | 56795 (95.7) | 2527 (4.3) | | AGTR1 (1166A > C) | 26458 (89.2) | 3021 (10.2) | 182 (0.6) | 55937 (94.3) | 3385 (5.7) | | ACE (I/D) | 13959 (47.1) | 12646 (42.6) | 3056 (10.3) | 40564 (68.4) | 18758 (31.6) | | CYP3A5 3 | 2783 (9.4) | 12473 (42.1) | 14405 (48.6) | 18039 (30.4) | 41283 (69.6) | | NPPA (2238T > C) | 29091 (98.1) | 443 (1.5) | 127 (0.4) | 58625 (98.8) | 697 (1.2) |
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WW, wild-type homozygotes; WM, heterozygous mutation; MM, homozygous mutation; W, wild type; M. mutant.
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