Association of Antihypertensive Drug-Related Gene Polymorphisms with Stroke in the Chinese Hypertensive Population

Table 3

Distribution of polymorphisms in genes related to antihypertensive drugs.

Gene loci	Genotype	Controls		Stroke patients		χ^2	P
		n	%	n	%
ADRB1 (1165G > C)	CC	15984	55.4	488	59.8	8.884	0.012
	GC	10950	38.0	268	32.8
	GG	1911	6.6	60	7.4
HWE-P		>0.05
CYP2D6 10	1/1	6085	21.1	170	20.8	3.097	0.213
	1/10	12522	43.4	333	40.8
	10/10	10238	35.5	313	38.4
HWE-P		<0.05
CYP2C9 3	1/1	26452	91.7	752	92.2	2.042	0.360
	1/3	2323	8.1	64	7.8
	3/3	70	0.2	0	0.0
HWE-P		>0.05
AGTR1 (1166A > C)	1166A/A	25721	89.2	737	90.3	1.585	0.453
	1166A/C	2948	10.2	73	8.9
	1166C/C	176	0.6	6	0.7
HWE-P		<0.05
ACE (I/D)	II	13564	47.0	395	48.4	0.666	0.717
	ID	12305	42.7	341	41.8
	DD	2976	10.3	80	9.8
HWE-P		>0.05
CYP3A5 3	1/1	2700	9.4	83	10.2	1.537	0.464
	1/3	12120	42.0	353	43.3
	3/3	14025	48.6	380	46.6
HWE-P		>0.05
NPPA (2238T > C)	2238T/T	28291	98.1	800	98.0	0.128	0.938
	2238T/C	430	1.5	13	1.6
	2238C/C	124	0.4	3	0.4
HWE-P		<0.05