International Journal of Hypertension

The Emerging Role of Heme Oxygenase and Its Metabolites in the Regulation of Cardiovascular Function


Publishing date
15 Apr 2012
Status
Published
Submission deadline
15 Oct 2011

Lead Editor

1Department of Physiology and Biophysics, Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, MS 39216, USA

2Department of Physiology and Pharmacology, The University of Toledo College of Medicine, Toledo, OH 43614, USA

3Department of Cardiology, Center for Medical Education and Career Development, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan

4Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padua, Via Giustiniani 2, 35100 Padua, Italy


The Emerging Role of Heme Oxygenase and Its Metabolites in the Regulation of Cardiovascular Function

Description

Heme oxygenses (HO), first discovered over forty years ago, are a family of enzymes responsible for the catabolism of heme and in this process generate metabolites with a wide variety of cardiovascular actions. Recent advances in our understanding of HO enzymes have demonstrated an important role for HO enzymes and metabolites, carbon monoxide (CO), and bilirubin, in the regulation of a wide variety of cardiovascular functions and in the prevention of many pathological conditions. Knowledge and understanding of the regulation of HO enzymes and the role of subsequently generated CO and bilirubin offers the opportunity for the selective targeting of this system for the development of novel therapies for the treatment of cardiovascular disease.

We invite investigators to contribute original research articles as well as review articles that will highlight the emerging role of heme oxygenase and its metabolites in the regulation of cardiovascular function. We are particularly interested in original research articles describing the role of HO and/or its metabolites in the development and prevention of cardiovascular diseases including hypertension, heart disease, atherosclerosis, kidney disease, diabetes, obesity, and stroke. Potential topics include, but are not limited to:

  • Recent developments regarding the role of HO and its metabolites in the regulation of blood pressure and the development of all forms of hypertension including portal and pulmonary
  • Recent developments regarding the role of HO and its metabolites in the pathogenesis of diabetes and obesity and inflammation
  • Recent developments regarding the role of HO and its metabolites in the development and progression of atherosclerosis, stroke, and other vascular diseases
  • Advances in the genetics/biochemistry of bilirubin metabolizing enzymes and their role in cardiovascular disease
  • Innovative techniques and developments in the therapeutic administration of carbon monoxide for the treatment of cardiovascular diseases

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijht/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 593530
  • - Editorial

The Emerging Role of Heme Oxygenase and Its Metabolites in the Regulation of Cardiovascular Function

David E. Stec | Kazunobu Ishikawa | ... | Nader G. Abraham
  • Special Issue
  • - Volume 2012
  • - Article ID 628147
  • - Research Article

Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway

Jian Cao | Nitin Puri | ... | Attallah Kappas
  • Special Issue
  • - Volume 2012
  • - Article ID 392890
  • - Research Article

The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury

Kiran Chandrashekar | Arnaldo Lopez-Ruiz | ... | Luis A. Juncos
  • Special Issue
  • - Volume 2012
  • - Article ID 842632
  • - Review Article

Heme Oxygenase-1 Induction and Organic Nitrate Therapy: Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress

Andreas Daiber | Matthias Oelze | ... | Hartmut Kleinert
  • Special Issue
  • - Volume 2012
  • - Article ID 236180
  • - Clinical Study

Role of HO/CO in the Control of Peripheral Circulation in Humans

David Sacerdoti | Despina Mania | ... | Massimo Bolognesi
  • Special Issue
  • - Volume 2012
  • - Article ID 890671
  • - Review Article

Oxidative Stress and Heme Oxygenase-1 Regulated Human Mesenchymal Stem Cells Differentiation

Luca Vanella | Christopher Sanford | ... | Nabil Ebraheim
  • Special Issue
  • - Volume 2012
  • - Article ID 957235
  • - Research Article

Induction of Hemeoxygenase-1 Reduces Renal Oxidative Stress and Inflammation in Diabetic Spontaneously Hypertensive Rats

Ahmed A. Elmarakby | Jessica Faulkner | ... | Jennifer C. Sullivan
  • Special Issue
  • - Volume 2012
  • - Article ID 127910
  • - Review Article

Novel Insights into the Vasoprotective Role of Heme Oxygenase-1

Emanuela Marcantoni | Luigia Di Francesco | ... | Paola Patrignani
  • Special Issue
  • - Volume 2012
  • - Article ID 948203
  • - Research Article

Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice

Kazunobu Ishikawa | Mohamad Navab | Aldons J. Lusis
  • Special Issue
  • - Volume 2012
  • - Article ID 189512
  • - Research Article

Renal Heme Oxygenase-1 Induction with Hemin Augments Renal Hemodynamics, Renal Autoregulation, and Excretory Function

Fady T. Botros | Leszek Dobrowolski | L. Gabriel Navar
International Journal of Hypertension
 Journal metrics
Acceptance rate43%
Submission to final decision120 days
Acceptance to publication27 days
CiteScore2.100
Impact Factor1.132
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