International Journal of Hypertension

Angiotensin-(1-7)/Angiotensin-Converting Enzyme 2/Mas Receptor Axis and Related Mechanisms


Publishing date
01 Feb 2012
Status
Published
Submission deadline
01 Aug 2011

1Department of Morphology, Federal University of Minas Gerais, 31.270-901 Belo Horizonte, MG, Brazil

2Department of Physiology and Functional Genomics, College of Medicine, University of Florida, P.O. Box, Gainesville, FL 100274, USA


Angiotensin-(1-7)/Angiotensin-Converting Enzyme 2/Mas Receptor Axis and Related Mechanisms

Description

Cardiovascular disease is America's leading health problem, and the leading cause of death. One person in three suffers from some form of cardiovascular disease. There is an urgent need to develop new therapeutic strategies to improve the cardiovascular diseases outcome. Very recent studies have demonstrated that the heptapeptide Angiotensin(Ang)-(1-7) holds important cardiovascular beneficial effects. These actions are generally mediated by activation of the G protein-coupled receptor Mas. As a result of these novel findings, Ang-(1-7), in combination with Mas and Angiotensin-converting enzyme (ACE) 2, the main enzyme involved in its formation, is thought to compose a cardioprotective branch within the renin-angiotensin system (RAS), which balances the ACE/Ang II/AT1 receptor effects. Consequently, new therapeutic approaches targeting the ACE2/Ang-(1-7)/Mas axis have been proposed.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the role of this axis on the cardiovascular system. We are particularly interested in articles describing advances in therapeutic approaches based on the ACE2/Ang-(1-7)/Mas axis to treat cardiovascular diseases. Potential topics include, but are not limited to:

  • Signaling pathways triggered by Mas activation
  • New insights into the ACE2/Ang-(1-7)/Mas axis using animal models
  • Innovative pharmacological therapies for cardiovascular diseases and pulmonary diseases based on the ACE2/Ang-(1-7)/Mas axis
  • Gene therapy strategies using ACE2, Ang-(1-7) and Mas
  • Inflammation, cardiovascular diseases, and ACE2/Ang-(1-7)/Mas axis
  • Brain, neurogenic hypertension, stroke, and ACE2/Ang-(1-7)/Mas axis

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijht/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 690785
  • - Editorial

Angiotensin-(1-7)/Angiotensin-Converting Enzyme 2/Mas Receptor Axis and Related Mechanisms

Anderson J. Ferreira | Robson A. S. Santos | Mohan K. Raizada
  • Special Issue
  • - Volume 2012
  • - Article ID 543062
  • - Research Article

Influence of Angiotensin II Subtype 2 Receptor ( R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subtype 1 Receptor ( R) Blockade

Emma S. Jones | M. Jane Black | Robert E. Widdop
  • Special Issue
  • - Volume 2012
  • - Article ID 493129
  • - Review Article

Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes

Enéas R. M. Gomes | Robson A. S. Santos | Silvia Guatimosim
  • Special Issue
  • - Volume 2012
  • - Article ID 428950
  • - Research Article

Recombinant Expression and Characterization of Human and Murine ACE2: Species-Specific Activation of the Alternative Renin-Angiotensin-System

Marko Poglitsch | Oliver Domenig | ... | Manfred Schuster
  • Special Issue
  • - Volume 2012
  • - Article ID 958298
  • - Research Article

AVE0991, a Nonpeptide Compound, Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation via Induction of Heme Oxygenase-1 and Downregulation of p-38 MAPK Phosphorylation

Chen Sheng-Long | Wu Yan-Xin | ... | Ma Hong
  • Special Issue
  • - Volume 2012
  • - Article ID 795452
  • - Research Article

Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats

Fúlvia D. Marques | Marcos B. Melo | ... | Robson A. S. Santos
  • Special Issue
  • - Volume 2012
  • - Article ID 414128
  • - Review Article

Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney

Sergio Veloso Brant Pinheiro | Ana Cristina Simões e Silva
  • Special Issue
  • - Volume 2012
  • - Article ID 762094
  • - Research Article

Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice

Sean E. Thatcher | Manisha Gupte | ... | Lisa A. Cassis
  • Special Issue
  • - Volume 2012
  • - Article ID 808726
  • - Research Article

Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury

Lívia Corrêa Barroso | Kátia Daniela Silveira | ... | Mauro Martins Teixeira
  • Special Issue
  • - Volume 2012
  • - Article ID 147825
  • - Review Article

New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis

Anderson J. Ferreira | Tatiane M. Murça | ... | Robson A. S. Santos
International Journal of Hypertension
 Journal metrics
Acceptance rate35%
Submission to final decision145 days
Acceptance to publication31 days
CiteScore1.820
Impact Factor1.865
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