Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights
Figure 3
Effect of SR140333 administration, either 30 minutes before or 1 hour after CLP, on lung (a) Phospho ERK1/2 and (b) Phospho-PKC Results shown are the mean S.E.M ( 6 in each group). “Vehicle + CLP” and “SR140333 + CLP” represent the groups that received vehicle and SR140333 treatment, respectively, commencing 30 minutes prior to CLP. “CLP + vehicle” and “CLP + SR140333” represent the groups that received vehicle and SR140333 treatment, respectively, 1 hour after CLP. Upper panels show representative western blot gel pictures of phosphorylated and total ERK1/2 and PKC for each of the groups. when vehicle-treated CLP animals were compared with sham group animals; when SR140333-treated CLP animals were compared with vehicle-treated CLP animals. CLP: cecal ligation and puncture; ERK: extracellular signal regulated kinase; IOD: integrated optical density; PKC: protein kinase C.
