The Role of Bacteria and Pattern Recognition Receptors in GvHD

Table 1

Summary of published studies on NOD2 SNPs and outcome following SCT.

	Type of SCT	Association	Comment	Refereces
Holler 2004	Related	GvHD, TRM	Single centre	[17]
Holler 2006	Related	GvHD, TRM, OS	Multicentre; Impact of decontamination	[18]
Granell 2006	Related	TRM, pulmonary compl.	CD34 selected grafts	[19]
Sairafi 2008	Related	No association	Low frequency of NOD2 variants	[22]
Hanssen 2008	Related	Weak with GvHD		[20]
Van Velden 2009	Related	Strong with GvHD	Partially T depleted Grafts	[21]
Hildebrandt 2009	Related and Unrelated	Bronchiolitis obliterans		[28]
Mayor 2009	Unrelated	Strong with relapse, not with GvHD	Majority received T-cell depletion With MabCampath	[25]
Holler 2009	Unrelated	Only SNP13 with TRM		[24]
Ngyen 2010	Unrelated	No		[23]