Decreased MI sizes in MyD88-knockout (KO) and KO→WT chimeric mice compared with wild-type (WT) and WT→WT chimeric mice. Mice were subjected to 30 min of ischemia and 24 h of reperfusion. At the end of reperfusion, animals were euthanized, and area-at-risk (AAR) and MI were analyzed. (a) Representative of triphenyltetra zolium chloride (TTC) staining (bottom) and fluorescent microsphere distribution (top) of myocardial sections from the 4 groups of mice. The nonischemic area is indicated by red fluorescent staining, area at risk (AAR) by area devoid of red fluorescent light, and infarct area by white. (b) Cumulative data of AAR/left ventricle (LV). (c) Cumulative data of MI/AAR. Each error bar represents mean ± SD of 6–9 mice. (Feng et al., [100], used with permission).
