Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification

Table 1

Table outlining the current state of knowledge of valve hemodynamic/mechanical parameters. Knowledge of these parameters will aid the design of in vitro or ex vivo experimental studies to study mechanobiology.

Mechanical parameter	Normal	Diseased	Notes
Pressure	120/80 mmHg	Hypertensive: >120/>80 mmHg
Membrane stress	Systole: 0.167 kPa		[3]
	Diastole: 2.4 kPa
Shear stress	Aortic side: peak 20 dyn/cm^2		[4, 5]
	Ventricular side: peak 64–71 dyn/cm^2
Peak flow velocity	1.20 m/s	7.0 m/s (Jet-like flow)	[6]
Bending strain and stress	Systole: 14.5% and 1.22 MPa		[7]
	Diastole: 8.3% and 0.71 MPa
Tensile strain and stress	Circumferential: 9–11%	Circumferential: >15%	Porcine AV [8]
	Radial: 13–25%	Radial: 15–31%