International Journal of Inflammation / 2011 / Article / Tab 1

Review Article

Inflammatory Concepts of Obesity

Table 1

Inflammatory cell types in adipose tissue.

Inflammatory cells in adipose tissue network of obesityComments

MacrophagesAccumulate in obese versus lean AT. Presence correlated with ↑ expression of inflammatory mediators in AT and metabolic disturbances [12, 13].
Infiltrative macrophages and M1 markers predominate over resident macrophages and M2 markers in obese AT [14].

T cellsFewer than macrophages, they also accumulate in obese versus lean AT [1517].
Depletion of CD8 lymphocytes from DIO-mice macrophage accumulation in AT and systemic IR [18].
CD4+ Foxp3+ T regulatory cells (Treg) decrease in AT of obese versus lean mice. Treg cells may keep homeostasis and limit inflammation in lean AT [19].

Mast cellsGenetic deficiency of mast cells or their pharmacological stabilization in DIO-mice weight gain, AT, and systemic inflammation, and improve glucose metabolism and energy expenditure [20].

NKT cellsDIO-mice lacking NKT cells present less AT inflammation and glucose intolerance than wild-type control animals [21].

AT: adipose tissue; DIO-mice: diet-induced obese mice.

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