Inflammatory cells in adipose tissue network of obesity
Comments
Macrophages
Accumulate in obese versus lean AT. Presence correlated with ↑ expression of inflammatory mediators in AT and metabolic disturbances [12, 13].
Infiltrative macrophages and M1 markers predominate over resident macrophages and M2 markers in obese AT [14].
T cells
Fewer than macrophages, they also accumulate in obese versus lean AT [15–17].
Depletion of CD8 lymphocytes from DIO-mice ↓ macrophage accumulation in AT and ↓ systemic IR [18].
CD4+ Foxp3+ T regulatory cells (Treg) decrease in AT of obese versus lean mice. Treg cells may keep homeostasis and limit inflammation in lean AT [19].
Mast cells
Genetic deficiency of mast cells or their pharmacological stabilization in DIO-mice ↓ weight gain, AT, and systemic inflammation, and improve glucose metabolism and energy expenditure [20].
NKT cells
DIO-mice lacking NKT cells present less AT inflammation and glucose intolerance than wild-type control animals [21].
