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International Journal of Inflammation
Volume 2011 (2011), Article ID 569416, 5 pages
Research Article

Cytotoxicity and Induction of Inflammation by Pepsin in Acid in Bronchial Epithelial Cells

1ELEGI, Colt Research Laboratories, MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH 16 4TJ, UK
2Department of Medical Microbiology, University Medical Center Utrecht, 3508 Utrecht, The Netherlands

Received 23 February 2011; Revised 17 May 2011; Accepted 20 May 2011

Academic Editor: Jean-Marc Cavaillon

Copyright © 2011 Erik Bathoorn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In our experiments, human bronchial epithelial cells were exposed to increasing pepsin concentrations in varying acidic milieus, and cell proliferation and cytokine release were assessed. In the article, we selected concentrations best representing the effects of pepsin to show in the figures. In the supplementary material, we present the figures of the effects of pepsin on cell survival and induction of cytokine release of all the pepsin concentrations and pH levels used in the statistical analysis.

  1. Supplementary Material