MMP-Activated Fluorescence Imaging Detects Early Joint Inflammation in Collagen-Antibody-Induced Arthritis in CC-Chemokine Receptor-2-Null Mice, In-Vivo
Figure 1
Clinical assessment of Ccr2−/− DBA1/J animals after receiving CAIA. The development of RA was examined clinically. Mice received immunization intravenously with collagen type II antibody or PBS (day 0) followed by lipopolysaccharide stimulation or with saline for control (day 3). (a) Increased susceptibility to arthritis in mice immunized (day 0) with collagen type II antibody (CAIA: ) compared to control mice (PBS: ) without a significant change in fore or hind paw thickness (b-c). Data is represented as the mean ± SD.
