Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis
Figure 5
Effect of iNOS inhibitor, 1400 W, and cNOS inhibitor, L-NAME, on the ghrelin (Gh)-induced changes in Akt kinase activity and mucin synthesis in the acinar cells. The cells, preincubated with 30 μM 1400 W (14 W) or 200 μM L-NAME (LN), were treated with Gh at 0.6 μg/mL and incubated for 16 h with the LPS at 100 ng/mL, in the presence of [3H]glucosamine as a marker of mucin synthesis. Values represent the means ± SD of five experiments. * compared with that of control. ** compared with that of LPS alone. *** compared with that of Gh + LPS.
