Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis
Figure 7
Effect of Akt inhibitor, SH-5, and ascorbate on the ghrelin- (Gh-) induced changes in mucin synthesis and Akt activity in the acinar cells exposed to P. gingivalis LPS. The cells, preincubated with 20 μM SH-5 (SH) or 300 μM ascorbate (As), were treated with Gh (0.6 μg/mL) and incubated for 16 h with the LPS at 100 ng/mL, in the presence of [3H]glucosamine as a marker of mucin synthesis. * compared with that of control. ** compared with that of LPS alone. *** compared with that of Gh + LPS.
