Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans
Table 1
Patient baseline measurements for carotid endarterectomy specimens.
Clinical characteristics
Total
Quartile of CXCL10 concentration
value*
1
2
3
4
CXCL10 pg/mL
38.3 (14–40) †
0–11.3
11.8–18.4
19.3–37.2
37.6–382.6
0.000
Age (years)†
68.4 ± 8.9
66.0 ± 8.0
68.3 ± 10.2
67.7 ± 8.2
71.2 ± 8.5
0.157
Male (%)
73.6
73.1
70.4
66.7
84.6
0.316
Hypertension (%)
71.7
80.0
70.4
66.7
79.2
0.764
Smoker (%)
24.5
30.8
18.5
32.0
19.2
0.476
Symptomatic disease (%)
86.8
84.6
85.2
92.6
84.6
0.762
Statin (%)
56.6
66.7
55.6
55.6
56.0
0.530
β blocker (%)
39.6
37.5
33.3
56.0
41.7
0.321
ACE inhibitor (%)
39.6
42.3
33.3
40.7
42.3
0.881
Serum values†
Total cholesterol (mmol/L)
4.9 ± 1.3
4.8 ± 0.9
5.2 ± 1.3
4.8 ± 1.7
4.6 ± 1.2
0.564
HDL (mmol/L)
1.2 ± 0.4
1.2 ± 0.4
1.4 ± 0.3
1.1 ± 0.3
1.1 ± 0.4
0.156
LDL (mmol/L)
3.0 ± 1.1
2.7 ± 0.8
3.3 ± 1.0
3.2 ± 1.4
2.7 ± 1.0
0.392
Triglycerides (mmol/L)
1.9 ± 0.9
2.3 ± 1.0
1.8 ± 0.8
2.0 ± 1.1
1.7 ± 0.7
0.434
ApoB (mmol/L)
0.9 ± 0.2
0.9 ± 0.2
1.0 ± 0.2
1.0 ± 0.3
0.9 ± 0.3
0.787
Glucose (mmol/L)
6.6 ± 1.9
5.8 ± 0.7
7.0 ± 2.0
7.0 ± 2.3
6.4 ± 1.9
0.129
CRP (mg/mL)
3.40
3.13
2.96
4.81
4.52
0.221
(1.6–7.3)
(1.4–5.8)
(1.8–5.8)
(1.7–9.1)
(1.6–7.3)
Baseline data of 106 patients were stratified into four quartiles according to plaque CXCL10 concentration. †Values are represented as mean ± SD or median (Inter Quartile Range) as appropriate. values based on ANOVA test between CXCL10 quartiles for continuous variables and nonparametric Mann-Whitney test for categorical variables.
