Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells: A Plausible Mechanism for Tissue Injury-Associated Pancreatitis
Figure 4
Transcription of type I interferon mRNA is induced by synthetic double-stranded DNA (dsDNA). (a) Extracellular DNA stimulation had no effect on the induction of type I interferons (IFNs), such as IFN-α and IFN-. In contrast, intracellular dsDNA (at 10 g/mL) has stimulatory effects on their expression, including the expression of their transcriptional factors interferon regulatory factor 1 (IRF1), IRF2, and IRF7 (b). TFx: + transfection reagent lipofectamine. *, **.
