Rapamycin Augments the NMDA-Mediated TNF Suppression of MRSA-Stimulated RAW264.7 Murine Macrophages
Figure 4
(a) Effects of rapamycin on RAW264.7 murine macrophages stimulated by LTA. Lipoteichoic acid (LTA) stimulated more TNF secretion by RAW264.7 murine macrophages when exposed to rapamycin at 0.1 and 1 ng/mL and less when exposed to rapamycin at 100 ng/mL. The response at 0.1 ng/mL had an increase of 10%, significantly different () from the untreated control (first column). The response at 10 ng/mL (third column) had a decrease of 8% (not significantly different), and the response at 100 ng/mL (fourth column) demonstrated a 13% decrease, significantly different from the control (). The results are depicted as fold of change compared to the control with 95% confidence intervals shown as “error bars.” . The control response was 31,684 pg/mL ± 713 pg/mL. (b) Effects of rapamycin on RAW264.7 murine macrophages stimulated by LTA. Lipoteichoic acid (LTA) stimulated more TNF secretion by RAW264.7 murine macrophages when exposed to rapamycin at 0.1 and 1 ng/mL and less when exposed to rapamycin at 100 ng/mL. (b) depicts (a) results with actual TNF (pg/mL) secretion, that is, 31.684(713), 34.852(889), 29149(809), and 27.565(593) pg/mL, respectively.
