International Journal of Inflammation / 2012 / Article / Fig 4

Research Article

Rapamycin Augments the NMDA-Mediated TNF Suppression of MRSA-Stimulated RAW264.7 Murine Macrophages

Figure 4

(a) Effects of rapamycin on RAW264.7 murine macrophages stimulated by LTA. Lipoteichoic acid (LTA) stimulated more TNF secretion by RAW264.7 murine macrophages when exposed to rapamycin at 0.1 and 1 ng/mL and less when exposed to rapamycin at 100 ng/mL. The response at 0.1 ng/mL had an increase of 10%, significantly different ( ) from the untreated control (first column). The response at 10 ng/mL (third column) had a decrease of 8% (not significantly different), and the response at 100 ng/mL (fourth column) demonstrated a 13% decrease, significantly different from the control ( ). The results are depicted as fold of change compared to the control with 95% confidence intervals shown as “error bars.” . The control response was 31,684 pg/mL ± 713 pg/mL. (b) Effects of rapamycin on RAW264.7 murine macrophages stimulated by LTA. Lipoteichoic acid (LTA) stimulated more TNF secretion by RAW264.7 murine macrophages when exposed to rapamycin at 0.1 and 1 ng/mL and less when exposed to rapamycin at 100 ng/mL. (b) depicts (a) results with actual TNF (pg/mL) secretion, that is, 31.684(713), 34.852(889), 29149(809), and 27.565(593) pg/mL, respectively.
542727.fig.004a
(a)
542727.fig.004b
(b)

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