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International Journal of Inflammation
Volume 2013, Article ID 151028, 8 pages
http://dx.doi.org/10.1155/2013/151028
Review Article

Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold

1Faculty of Medicine, University Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany
2Department of Research and Development, Institute for Neuropathic Pain, Spoorlaan 2a, 3735 MV Bosch en Duin, The Netherlands
3Division of Human Nutrition (Bode 62), Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands

Received 3 April 2013; Revised 9 June 2013; Accepted 10 June 2013

Academic Editor: Juan Carlos Kaski

Copyright © 2013 J. M. Keppel Hesselink et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [22 citations]

The following is the list of published articles that have cited the current article.

  • Keppel Hesselink, “Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: A case collection,” International Medical Case Reports Journal, vol. 6, no. 1, pp. 49–53, 2013. View at Publisher · View at Google Scholar
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  • Jan M. Keppel Hesselink, David J. Kopsky, and Nancy L. Sajben, “Vulvodynia and proctodynia treated with topical baclofen 5 % and palmitoylethanolamide,” Archives of Gynecology and Obstetrics, 2014. View at Publisher · View at Google Scholar
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  • Renger Witkamp, and Jocelijn Meijerink, “The endocannabinoid system,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 17, no. 2, pp. 130–138, 2014. View at Publisher · View at Google Scholar
  • Rutger Kriek, “Palmitoylethanolamide: problems regarding micronization, ultra-micronization and additives,” Inflammopharmacology, 2014. View at Publisher · View at Google Scholar
  • M. Coppola, and R. Mondola, “Is there a role for palmitoylethanolamide in the treatment of depression ?,” Medical Hypotheses, 2014. View at Publisher · View at Google Scholar
  • Francesca Borrelli, Barbara Romano, Stefania Petrosino, Ester Pagano, Raffaele Capasso, Diana Coppola, Giovanni Battista, Pierangelo Orlando, Vincenzo Di Marzo, and Angelo A Izzo, “Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent,” British Journal of Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Renger Witkamp, “Fatty acids, endocannabinoids and inflammation,” European Journal of Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Lorenzo Di Cesare Mannelli, Alessandra Pacini, Francesca Corti, Serena Boccella, Livio Luongo, Emanuela Esposito, Salvatore Cuzzocrea, Sabatino Maione, Antonio Calignano, and Carla Ghelardini, “Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity,” Plos One, vol. 10, no. 6, 2015. View at Publisher · View at Google Scholar
  • Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, and David J. Kopsky, “Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy,” Journal of Ophthalmology, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Peter O. Fayemi, Voster Muchenje, Hasan Yetim, and Abdulatef Ahhmed, “Targeting the pains of food insecurity and malnutrition among internally displaced persons with nutrient synergy and analgesics in organ meat,” Food Research International, 2016. View at Publisher · View at Google Scholar
  • Jan M. Keppel Hesselink, “Fundamentals of and Critical Issues in Lipid Autacoid Medicine: A Review,” Pain and Therapy, 2017. View at Publisher · View at Google Scholar
  • J.M. Keppel Hesselink, “Palmitoylethanolamid and Other Lipid Autacoids Against Neuroinflammation, Pain, and Spasms in Multiple Sclerosis,” Nutrition and Lifestyle in Neurological Autoimmune Diseases, pp. 29–37, 2017. View at Publisher · View at Google Scholar
  • Lorenzo Di Cesare Mannelli, Laura Micheli, Elena Lucarini, and Carla Ghelardini, “N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Alexandra Maria Koenig, Wei Gao, Maria Umlauft, Katharina Schury, Frank Reister, Clemens Kirschbaum, Alexander Karabatsiakis, and Iris-Tatjana Kolassa, “Altered hair endocannabinoid levels in mothers with childhood maltreatment and their newborns,” Biological Psychology, 2018. View at Publisher · View at Google Scholar
  • Ev Christin Heide, Laura Bindila, Julia Maria Post, Dörthe Malzahn, Beat Lutz, Jana Seele, Roland Nau, and Sandra Ribes, “Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar