Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration
Figure 5
Ccr2 chemokine receptor signaling is required for macrophage recruitment to the outer retina after CEP-MSA immunization. (a) Anti-CEP antibody titers were examined following immunization of WT versus B6 mice (). Naïve mice have no anti-CEP titers. Mean values are shown; error bars represent S.D. (b) Retinal pathology scores for the indicated groups at the late time point (day 200+ p.i.; ). (*) denotes statistically significant difference (); ns: not significant. Data from one representative experiment was used for this analysis; similar results were obtained in a separate independent experiment.
