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International Journal of Inflammation
Volume 2013, Article ID 503725, 12 pages
Research Article

Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration

1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
2Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
3Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
4Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA
5Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
6Ophthalmology, Immunology & Microbiology, University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Miami, FL 33136, USA

Received 17 October 2012; Revised 20 December 2012; Accepted 24 January 2013

Academic Editor: Robert B. Nussenblatt

Copyright © 2013 Fernando Cruz-Guilloty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material includes 3 figures showing another example of photoreceptor cell loss in CEP-immunized mice and accompanying inflammatory cells in the choroid and outer retina

  1. Supplementary Material