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International Journal of Inflammation
Volume 2013, Article ID 609628, 7 pages
Review Article

Necrotizing Soft Tissue Infections: Surgeon’s Prospective

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

Received 26 June 2013; Revised 8 September 2013; Accepted 11 October 2013

Academic Editor: Jonathan Steven Alexander

Copyright © 2013 Shashi Prakash Mishra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Necrotizing soft tissue infections (NSTIs) are fulminant infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Delay in diagnosing and treating these infections increases the risk of mortality. Early and aggressive surgical debridement with support for the failing organs significantly improves the survival. Although there are different forms of NSTIs like Fournier’s gangrene or clostridial myonecrosis, the most important fact is that they share common pathophysiology and principles of treatment. The current paper summarizes the pathophysiology, clinical features, the diagnostic workup required and the treatment principles to manage these cases.