Differential Role of Rapamycin and Torin/KU63794 in Inflammatory Response of 264.7 RAW Macrophages Stimulated by CA-MRSA

Table 2

The table indicates the reduction from the control of RAW264.7 macrophages inflammatory response in the presence of 0, 0.1, 10, and 100 ng/mL Rapamycin (up) and Rapamycin and Torin 5 ng/mL (down).

	TNF; (%-pg/mL)	IL-1; (%-pg/mL)	IL-6; (%-pg/mL)	INF; (%-pg/mL)	NO; (%-μM)
Rapamycin (ng/mL)
0	100%; 32,758 ± 3,603	100%; 486 ± 58	100%; 799 ± 96	100%; 87 ± 10	100%; 22.1 ± 2.7
0.1	115%*	100%	113%*	102%	115%*
10	66%*	62%*	75%*	65%*	64%*
100	64%*	61%*	81%*	67%*	63%*
Rapamycin and Torin at 5 ng/mL
0 and no Torin	100%; 34,231 ± 3,765	100%; 396 ± 48	100%; 831 ± 100	100%; 89 ± 11	100%; 22.7 ± 2.7
0.1	49%*	43%*	80%*	50%*	54%*
10	43%*	40%*	79%*	47%*	48%*
100	41%*	39%*	83%*	44%*	43%*

The first line indicates the response without Rapamycin (up) or without Rapamycin and Torin (down) which is used as control (100% response) and the subsequent values are expressed as % of such responses.
*Indicates statistical significance (𝑃<0.05) from the control.
TNF: tumor necrosis factor, IL-1: interleukin 1, IL-6: interleukin 6, INF: interferon, and NO: nitric oxide.