Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents
Table 4
Effect of AE and AEC on paw edema volume in carrageenan induced paw edema in rats.
Groups
Paw edema volume in mL at
0.5 h
1 h
2 h
3 h
4 h
5 h
24 h
I Control
0.44 ± 0.007
0.50 ± 0.01
0.54 ± 0.009
0.54 ± 0.006
0.56 ± 0.008
0.57 ± 0.009
0.27 ± 0.009
II-Std.
0.30 ± 0.008∗∗
0.35 ± 0.07∗∗
0.34 ± 0.009∗∗
0.32 ± 0.008∗∗
0.27 ± 0.008∗∗
0.24 ± 0.004∗∗
0.08 ± 0.007∗∗
III-AE 25
0.42 ± 0.007
0.48 ± 0.012
0.50 ± 0.006
0.52 ± 0.006
0.53 ± 0.006
0.54 ± 0.007
0.25 ± 0.004
IV-AE 50
0.40 ± 0.009∗
0.46 ± 0.01∗
0.47 ± 0.006∗∗
0.45 ± 0.01∗∗
0.41 ± 0.009∗∗
0.39 ± 0.008∗∗
0.20 ± 0.007∗∗
V-AE 75
0.36 ± 0.008∗∗
0.41 ± 0.01∗∗
0.42 ± 0.013∗∗
0.40 ± 0.010∗∗
0.38 ± 0.007∗∗
0.36 ± 0.008∗∗
0.17 ± 0.009∗∗
VI-AEC 25
0.41 ± 0.006
0.48 ± 0.009
0.49 ± 0.008
0.51 ± 0.007
0.53 ± 0.007
0.53 ± 0.008
0.25 ± 0.006
VII-AEC 50
0.35 ± 0.007∗∗
0.40 ± 0.007∗∗
0.41 ± 0.009∗∗
0.41 ± 0.001∗∗
0.38 ± 0.010∗∗
0.35 ± 0.007∗∗
0.16 ± 0.004∗∗
VIII-AEC 75
0.35 ± 0.011∗∗
0.38 ± 0.008∗∗
0.39 ± 0.006∗∗
0.37 ± 0.012∗∗
0.35 ± 0.025∗∗
0.33 ± 0.005∗∗
0.13 ± 0.009∗∗
Results are presented as mean ± SEM (). The data was analysed using one-way analysis of variance (ANOVA) followed by Dunnett test. ∗, ∗∗ when compared with arthritic control group. AC: arthritic control; Std.: Diclofenac sodium 10 mg/kg p.o.; AE: aloe emodin (25, 50, and 75 mg/kg p.o.); AEC: carboxylic acid derivative of aloe emodin (25, 50, and 75 mg/kg p.o.).
