Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents

Table 5

Effect of AE and AEC on hematological parameters (RBCs, WBCs, and Hb) in Freund’s complete adjuvant induced arthritic rats.

Groups ()	RBC (millions/cubic mm)	WBC (10^3/cubic mm)	Hb (gm%)
I-AC	5.83 ± 0.600	14.83 ± 0.872	9.16 ± 0.477
II-Std.	9.66 ± 0.666^∗∗	6.83 ± 0.703^∗∗	14.83 ± 0.872^∗∗
III-AE 25	6.50 ± 0.562	12.33 ± 1.054	10.50 ± 0.763
IV-AE 50	8.66 ± 0.333^∗∗	9.16 ± 0.477^∗∗	12.50 ± 0.428^∗∗
V-AE 75	8.83 ± 0.703^∗∗	8.50 ± 0.428^∗∗	12.33 ± 0.557^∗∗
VI-AEC 25	6.33 ± 0.494	11.83 ± 0.792^∗	11.00 ± 0.577
VII-AEC 50	8.83 ± 0.401^∗∗	8.83 ± 0.477^∗∗	12.83 ± 0.477^∗∗
VIII-AEC 75	9.00 ± 0.577^∗∗	8.00 ± 0.365^∗∗	13.16 ± 0.703^∗∗

Results are presented as mean ± SEM (). The data was analysed using one-way analysis of variance (ANOVA) followed by Dunnett test. ^∗, ^∗∗ when compared with arthritic control group. AC: arthritic control; Std.: Diclofenac sodium 10 mg/kg p.o.; AE: aloe emodin (25, 50, and 75 mg/kg p.o.); AEC: carboxylic acid derivative of aloe emodin (25, 50, and 75 mg/kg p.o.).