Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents

Table 6

Effect of AE and AEC on RF and ESR levels in Freund’s complete adjuvant induced arthritic rats.

Groups ()	RF (IU/L)	ESR (mm/hr)
I-AC	46.16 ± 1.138	10.83 ± 0.600
II-Std.	25.66 ± 0.988^∗∗	5.50 ± 0.670^∗∗
III-AE 25	42.83 ± 0.792	9.33 ± 0.494
IV-AE 50	36.83 ± 0.909^∗∗	7.50 ± 0.428^∗∗
V-AE 75	34.16 ± 0.600^∗∗	6.83 ± 0.600^∗∗
VI-AEC 25	41.83 ± 0.872^∗	9.00 ± 0.516
VII-AEC 50	32.50 ± 0.846^∗∗	7.00 ± 0.365^∗∗
VIII-AEC 75	29.33 ± 1.054^∗∗	6.16 ± 0.477^∗∗

Results are presented as mean ± SEM (). The data was analysed using one-way analysis of variance (ANOVA) followed by Dunnett test. ^∗, ^∗∗ when compared with arthritic control group. AC: arthritic control; Std.: Diclofenac sodium 10 mg/kg p.o.; AE: aloe emodin (25, 50, and 75 mg/kg p.o.); AEC: carboxylic acid derivative of aloe emodin (25, 50, and 75 mg/kg p.o.).