Role of MicroRNAs in Renin-Angiotensin-Aldosterone System-Mediated Cardiovascular Inflammation and Remodeling

Table 2

MicroRNAs affected by RAAS inhibitors.

Inhibitor	MicroRNA target gene	Reference
Aliskiren
↓ miR-106-5p	EGFR/AKT/mTOR, ACE	[27]
↓ miR-27a-3p	EGFR/AKT/mTOR, ACE	[26–28, 38]
↓ miR-18b-5p	EGFR, ACE	[29]
↓ miR-155	AT1R
Candesartan
↑ miR-483-3p	AGT, ACE-1, ACE-2, AT2R	[26, 38]
↓ miR-132/122	Ang II	[38]
↓ miR-29b	Col1A, Col3A1	[26, 38]
↓ miR-212	AT2R
Telmisartan
↑ miR-31		[30]
↑ miR-181a	TNFalpha	[30]
↑ miR-16	VEGF	[30]
↑ miR-143/145	KLF4, KLF6, ACE-2	[30]
↓ miR-146a/b	TRAF6, KLF4, TLR4	[31]
Atorvastatin
↓ miR-146a/b	TRAF6, KLF4, TLR4	[31]
↓ miR-221/222	p27, p57	[50]
Enalapril
↑ miR-31		[30]
↑ miR-181a	TNFalpha	[30]
↑ miR-145	KLF4, KLF6, ACE-2	[30]
↑ miR-16	VEGF, CCND1, CCND2, CCNE	[30, 47]
Captopril
↑ miR-16	VEGF	[30, 47]
↑ miR-19b	βMHC	[47, 51]
↑ miR-20b		[47]
↑ miR-93		[47]
↑ miR-106b		[47]
↑ miR-223		[47]
↑ miR-423-5p		[47]

Note: ↓: decreased expression level; ↑: increased expression level.