Table of Contents Author Guidelines Submit a Manuscript
International Journal of Inflammation
Volume 2015, Article ID 329792, 8 pages
http://dx.doi.org/10.1155/2015/329792
Research Article

Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization

1Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil
2University of São Paulo School of Medicine, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
3São Paulo Adventist University Center, Estrada de Itapecerica, 5859 Jardim IAE, 05858-001 São Paulo, SP, Brazil
4Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil
5Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Domingo de Soto 100, Vila Mariana, 04116-030 São Paulo, SP, Brazil
6Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Hacettepe University Faculty of Medicine, Sıhhiye, 06100 Ankara, Turkey
7Center for Sensory-Motor Interaction, School of Medicine, Aalborg University, Fredrik Bajers Vej 7, Building D3, 9220 Aalborg E, Denmark

Received 12 November 2014; Revised 23 December 2014; Accepted 23 January 2015

Academic Editor: David A. Hart

Copyright © 2015 Marta Imamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. M. Alkan, F. Fidan, A. Tosun, and Ö. Ardiçoǧlu, “Quality of life and self-reported disability in patients with knee osteoarthritis,” Modern Rheumatology, vol. 24, no. 1, pp. 166–171, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Kotlarz, C. L. Gunnarsson, H. Fang, and J. A. Rizzo, “Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data,” Arthritis and Rheumatism, vol. 60, no. 12, pp. 3546–3553, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. D. C. Ang, G. James, and T. E. Stump, “Clinical appropriateness and not race predicted referral for joint arthroplasty,” Arthritis Care and Research, vol. 61, no. 12, pp. 1677–1685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. A. J. Fellet, A. F. Afonso, and L. F. Barbosa, “Osteoarthrosis: uma revisão,” Revista Brasileira de Medicina, vol. 64, no. 11, pp. 55–61, 2007. View at Google Scholar · View at Scopus
  5. W. Zhang, G. Nuki, R. W. Moskowitz et al., “OARSI recommendations for the management of hip and knee osteoarthritis. Part III: changes in evidence following systematic cumulative update of research published through January 2009,” Osteoarthritis and Cartilage, vol. 18, no. 4, pp. 476–499, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Livshits, G. Zhai, D. J. Hart et al., “Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study,” Arthritis and Rheumatism, vol. 60, no. 7, pp. 2037–2045, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. B. Goldring, M. Otero, D. A. Plumb et al., “Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis,” European Cells and Materials, vol. 21, pp. 202–220, 2011. View at Google Scholar · View at Scopus
  8. N. Saetan, S. Honsawek, A. Tanavalee, S. Tantavisut, P. Yuktanandana, and V. Parkpian, “Association of plasma and synovial fluid interferon-γ inducible protein-10 with radiographic severity in knee osteoarthritis,” Clinical Biochemistry, vol. 44, no. 14-15, pp. 1218–1222, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Kumm, A. Tamm, M. Lintrop, and A. Tamm, “The value of cartilage biomarkers in progressive knee osteoarthritis: cross-sectional and 6-year follow-up study in middle-aged subjects,” Rheumatology International, vol. 33, no. 4, pp. 903–911, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. E. B. Dam, I. Byrjalsen, L. Arendt-Nielsen, C. Christiansen, and M. A. Karsdal, “Relationships between knee pain and osteoarthritis biomarkers based on systemic fluids and magnetic resonance imaging,” Journal of Musculoskeletal Pain, vol. 19, no. 3, pp. 144–153, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Garnero, “Biochemical markers of bone remodeling,” Annales de Biologie Clinique, vol. 59, article 298, 2001. View at Google Scholar
  12. M. Ishijima, T. Watari, K. Naito et al., “Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis,” Arthritis Research & Therapy, vol. 13, article R22, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. D. M. Vigushin, M. B. Pepys, and P. N. Hawkins, “Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease,” Journal of Clinical Investigation, vol. 91, no. 4, pp. 1351–1357, 1993. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Ferrucci, B. W. J. H. Penninx, S. Volpato et al., “Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels,” Journal of the American Geriatrics Society, vol. 50, no. 12, pp. 1947–1954, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. G. D. Miller, B. J. Nicklas, and R. F. Loeser, “Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy,” Journal of the American Geriatrics Society, vol. 56, no. 4, pp. 644–651, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. B. W. J. H. Penninx, H. Abbas, W. Ambrosius et al., “Inflammatory markers and physical function among older adults with knee osteoarthritis,” Journal of Rheumatology, vol. 31, no. 10, pp. 2027–2031, 2004. View at Google Scholar · View at Scopus
  17. K. C. Deere, J. Clinch, K. Holliday et al., “Obesity is a risk factor for musculoskeletal pain in adolescents: findings from a population-based cohort,” Pain, vol. 153, no. 9, pp. 1932–1938, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Imamura, S. T. Imamura, H. H. S. Kaziyama et al., “Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis,” Arthritis Care and Research, vol. 59, no. 10, pp. 1424–1431, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Arendt-Nielsen, H. Nie, M. B. Laursen et al., “Sensitization in patients with painful knee osteoarthritis,” Pain, vol. 149, no. 3, pp. 573–581, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Graven-Nielsen, T. Wodehouse, R. M. Langford, L. Arendt-Nielsen, and B. L. Kidd, “Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement,” Arthritis and Rheumatism, vol. 64, no. 9, pp. 2907–2916, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. A. K. Suokas, D. A. Walsh, D. F. McWilliams et al., “Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis,” Osteoarthritis and Cartilage, vol. 20, no. 10, pp. 1075–1085, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. D. T. Felson, “The sources of pain in knee osteoarthritis,” Current Opinion in Rheumatology, vol. 17, no. 5, pp. 624–628, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. P. H. Finan, L. F. Buenaver, S. C. Bounds et al., “Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization,” Arthritis and Rheumatism, vol. 65, no. 2, pp. 363–372, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Altman, E. Asch, and D. Bloch, “Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association,” Arthritis and Rheumatism, vol. 29, no. 8, pp. 1039–1049, 1986. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Ravaud, G.-R. Auleley, C. Chastang et al., “Knee joint space width measurement: an experimental study of the influence of radiographic procedure and joint positioning,” British Journal of Rheumatology, vol. 35, no. 8, pp. 761–766, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Bellamy, W. W. Buchanan, C. H. Goldsmith, J. Campbell, and L. W. Stitt, “Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee,” Journal of Rheumatology, vol. 15, no. 12, pp. 1833–1840, 1988. View at Google Scholar · View at Scopus
  27. J. Keegan and F. D. Garrett, “The segmental distribution of the cutaneous nerves in the limbs of man,” The Anatomical Record, vol. 102, no. 4, pp. 409–437, 1948. View at Publisher · View at Google Scholar
  28. A. D. Farasyn, R. Meeusen, and J. Nijs, “Validity of cross-friction algometry procedure in referred muscle pain syndromes: preliminary results of a new referred pain provocation technique with the aid of a Fischer pressure algometer in patients with nonspecific low back pain,” Clinical Journal of Pain, vol. 24, no. 5, pp. 456–462, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Curfs, J. Meis, and J. Hoogkamp-Korstanje, “A primer on cytokines: sources, receptors, effects, and inducers,” Clinical Microbiology Reviews, vol. 10, no. 4, pp. 742–780, 1997. View at Google Scholar · View at Scopus
  30. J.-P. Pelletier, J. Martel-Pelletier, and S. B. Abramson, “Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets,” Arthritis & Rheumatism, vol. 44, no. 6, pp. 1237–1247, 2001. View at Publisher · View at Google Scholar
  31. F. A. J. van de Loo, S. Veenbergen, B. van den Brand et al., “Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function,” Arthritis and Rheumatism, vol. 64, no. 10, pp. 3313–3323, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Saxne, M. Lindell, B. Månsson, I. F. Petersson, and D. Heinegård, “Inflammation is a feature of the disease process in early knee joint osteoarthritis,” Rheumatology, vol. 42, no. 7, pp. 903–904, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. T. D. Spector, D. J. Hart, D. Nandra et al., “Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease,” Arthritis and Rheumatism, vol. 40, no. 4, pp. 723–727, 1997. View at Publisher · View at Google Scholar · View at Scopus
  34. K. F. Ferraro and T. L. Booth, “Age, body mass index, and functional illness,” Journals of Gerontology—Series B Psychological Sciences and Social Sciences, vol. 54, no. 6, pp. S339–S348, 1999. View at Google Scholar · View at Scopus
  35. O. Stannus, G. Jones, F. Cicuttini et al., “Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults,” Osteoarthritis and Cartilage, vol. 18, no. 11, pp. 1441–1447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Ding, F. Cicuttini, V. Parameswaran, O. Stannus, J. Burgess, and G. Jones, “045 serum levels of inflammatory markers, knee radiographic osteoarthritis, and knee cartilage loss in older adults,” Osteoarthritis and Cartilage, vol. 17, p. S33, 2009. View at Publisher · View at Google Scholar
  37. C. R. Scanzello, E. Umoh, F. Pessler et al., “Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease,” Osteoarthritis and Cartilage, vol. 17, no. 8, pp. 1040–1048, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. A. D. Pearle, C. R. Scanzello, S. George et al., “Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis,” Osteoarthritis and Cartilage, vol. 15, no. 5, pp. 516–523, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. M. L. A. S. Santos, W. F. Gomes, D. S. Pereira et al., “Muscle strength, muscle balance, physical function and plasma interleukin-6 (IL-6) levels in elderly women with knee osteoarthritis (OA),” Archives of Gerontology and Geriatrics, vol. 52, no. 3, pp. 322–326, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Lundborg, M. Hahn-Zoric, B. Biber, and E. Hansson, “Glial cell line-derived neurotrophic factor is increased in cerebrospinal fluid but decreased in blood during long-term pain,” Journal of Neuroimmunology, vol. 220, no. 1-2, pp. 108–113, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. D. J. Wallace, M. Linker-Israeli, D. Hallegua, S. Silverman, D. Silver, and M. H. Weisman, “Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study,” Rheumatology, vol. 40, no. 7, pp. 743–749, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Gur, M. Karakoc, S. Erdogan, K. Nas, R. Cevik, and A. J. Sarac, “Regional cerebral blood flow and cytokines in young females with fibromyalgia,” Clinical and Experimental Rheumatology, vol. 20, no. 6, pp. 753–760, 2002. View at Google Scholar · View at Scopus
  43. J. P. Shah, T. M. Phillips, J. V. Danoff, and L. H. Gerber, “An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle,” Journal of Applied Physiology, vol. 99, no. 5, pp. 1977–1984, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. J. P. Shah and E. A. Gilliams, “Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome,” Journal of Bodywork and Movement Therapies, vol. 12, no. 4, pp. 371–384, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. J. P. Shah, J. V. Danoff, M. J. Desai et al., “Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points,” Archives of Physical Medicine and Rehabilitation, vol. 89, no. 1, pp. 16–23, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. B. Å. S. Borge, K.-H. Kalland, S. Olsen, A. Bletsa, E. Berggreen, and H. Wiig, “Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 296, no. 3, pp. H735–H744, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Baylis, D. B. Bartlett, H. P. Patel, and H. C. Roberts, “Understanding how we age: insights into inflammaging,” Longevity & Healthspan, vol. 2, no. 1, article 8, 2013. View at Publisher · View at Google Scholar
  48. J. A. Woods, K. R. Wilund, A. S. Martin, and B. M. Kistler, “Exercise, inflammation and aging,” Aging and Disease, vol. 3, no. 1, pp. 130–140, 2012. View at Google Scholar
  49. V. Mohamed-Ali, S. Goodrick, A. Rawesh et al., “Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 12, pp. 4196–4200, 1997. View at Google Scholar · View at Scopus
  50. M. Bulló, P. García-Lorda, I. Megias, and J. Salas-Salvadó, “Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression,” Obesity Research, vol. 11, no. 4, pp. 525–531, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Imamura, R. A. Targino, W. T. Hsing et al., “Concentration of cytokines in patients with osteoarthritis of the knee and fibromyalgia,” Clinical Interventions in Aging, vol. 9, pp. 939–944, 2014. View at Publisher · View at Google Scholar
  52. K. J. Tracey and A. Cerami, “Tumor necrosis factor, other cytokines and disease,” Annual Review of Cell Biology, vol. 9, pp. 317–343, 1993. View at Publisher · View at Google Scholar · View at Scopus