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International Journal of Inflammation
Volume 2015 (2015), Article ID 943497, 14 pages
http://dx.doi.org/10.1155/2015/943497
Review Article

Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response

1Catedra de Terapia Celular, Escuela de Medicina, Tecnológico de Monterrey, Avenida Morones Prieto 3000 Pte., 64710 Monterrey, NL, Mexico
2Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez 162, 06720 Ciudad de México, DF, Mexico

Received 12 September 2014; Accepted 29 November 2014

Academic Editor: David A. Hart

Copyright © 2015 Florent Duval et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Mormone, J. George, and N. Nieto, “Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches,” Chemico-Biological Interactions, vol. 193, no. 3, pp. 225–231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. E. L. Ellis and D. A. Mann, “Clinical evidence for the regression of liver fibrosis,” Journal of Hepatology, vol. 56, no. 5, pp. 1171–1180, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Sánchez-Valle, N. C. Chávez-Tapia, M. Uribe, and N. Méndez-Sánchez, “Role of oxidative stress and molecular changes in liver fibrosis: a review,” Current Medicinal Chemistry, vol. 19, no. 28, pp. 4850–4860, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. L. Friedman, “Liver fibrosis—from bench to bedside,” Journal of Hepatology, vol. 38, pp. S38–S53, 2003. View at Google Scholar · View at Scopus
  5. T. Poynard, P. Mathurin, C.-L. Lai et al., “A comparison of fibrosis progression in chronic liver diseases,” Journal of Hepatology, vol. 38, no. 3, pp. 257–265, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. Y.-S. Lim and W. R. Kim, “The global impact of hepatic fibrosis and end-stage liver disease,” Clinics in Liver Disease, vol. 12, no. 4, pp. 733–746, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. H. L. Reeves and S. L. Friedman, “Activation of hepatic stellate cells: a key issue in liver fibrosis,” Frontiers in Bioscience, vol. 7, pp. d808–d826, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. N. C. Henderson and J. P. Iredale, “Liver fibrosis: cellular mechanisms of progression and resolution,” Clinical Science, vol. 112, no. 5-6, pp. 265–280, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. H.-S. Yi and W.-I. Jeong, “Interaction of hepatic stellate cells with diverse types of immune cells: foe or friend?” Journal of Gastroenterology and Hepatology, vol. 28, no. 1, pp. 99–104, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Duval, J. E. Moreno-Cuevas, M. T. González-Garza, C. Rodríguez-Montalvo, and D. E. Cruz-Vega, “Liver fibrosis and mechanisms of the protective action of medicinal plants—targeting hepatic stellate cell activation and extracellular matrix deposition,” Chinese Medicine. In press.
  11. T. Lisman and R. J. Porte, “The role of platelets in liver inflammation and regeneration,” Seminars in Thrombosis and Hemostasis, vol. 36, no. 2, pp. 170–174, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Lesurtel, R. Graf, B. Aleil et al., “Platelet-derived serotonin mediates liver regeneration,” Science, vol. 312, no. 5770, pp. 104–107, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Morales-Ibanez and R. Bataller, “Platelet-derived chemokines: new targets to treat liver fibrosis,” Journal of Hepatology, vol. 54, no. 3, pp. 581–583, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. M. Zaldivar, K. Pauels, P. Von Hundelshausen et al., “CXC chemokine ligand 4 (CXCl4) is a platelet-derived mediator of experimental liver fibrosis,” Hepatology, vol. 51, no. 4, pp. 1345–1353, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. S. K. Ramaiah and H. Jaeschke, “Role of neutrophils in the pathogenesis of acute inflammatory liver injury,” Toxicologic Pathology, vol. 35, no. 6, pp. 757–766, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Ibusuki, H. Uto, S. Arima et al., “Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet,” Liver International, vol. 33, no. 10, pp. 1549–1556, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. Z. Tan, X. Qian, R. Jiang et al., “IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation,” The Journal of Immunology, vol. 191, no. 4, pp. 1835–1844, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. J. S. Gujral, A. Farhood, M. L. Bajt, and H. Jaeschke, “Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice,” Hepatology, vol. 38, no. 2, pp. 355–363, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Saito, M. K. Bostick, C. B. Campe, J. Xu, and J. J. Maher, “Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis,” Hepatology Research, vol. 25, no. 2, pp. 180–191, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. W. Harty, C. S. Muratore, E. F. Papa et al., “Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers,” The American Journal of Pathology, vol. 176, no. 3, pp. 1271–1281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Franceschini, G. Ceva-Grimaldi, C. Russo, N. Dioguardi, and F. Grizzi, “The complex functions of mast cells in chronic human liver diseases,” Digestive Diseases and Sciences, vol. 51, no. 12, pp. 2248–2256, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. D. J. Farreil, J. E. Hines, A. F. Walls, P. J. Kelly, M. K. Bennett, and A. D. Burt, “Intrahepatic mast cells in chronic liver diseases,” Hepatology, vol. 22, no. 4, pp. 1175–1181, 1995. View at Google Scholar · View at Scopus
  23. T. Okazaki, S. Hirota, Z.-D. Xu et al., “Increase of mast cells in the liver and lung may be associated with but not a cause of fibrosis: demonstration using mast cell-deficient Ws/Ws rats,” Laboratory Investigation, vol. 78, no. 11, pp. 1431–1438, 1998. View at Google Scholar · View at Scopus
  24. A. Sugihara, T. Tsujimura, Y. Fujita, Y. Nakata, and N. Terada, “Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice,” Journal of Hepatology, vol. 30, no. 5, pp. 859–867, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. Cairns and A. F. Walls, “Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts,” The Journal of Clinical Investigation, vol. 99, no. 6, pp. 1313–1321, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. B. L. Gruber, R. R. Kew, A. Jelaska et al., “Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis,” The Journal of Immunology, vol. 158, no. 5, pp. 2310–2317, 1997. View at Google Scholar · View at Scopus
  27. A. Wehr, C. Baeck, F. Heymann et al., “Chemokine receptor cxcr6-dependent hepatic NK T cell accumulation promotes inflammation and liver fibrosis,” The Journal of Immunology, vol. 190, no. 10, pp. 5226–5236, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Ishikawa, K. Ikejima, H. Yamagata et al., “CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice,” Journal of Hepatology, vol. 54, no. 6, pp. 1195–1204, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. W.-K. Syn, K. M. Agboola, M. Swiderska et al., “NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease,” Gut, vol. 61, no. 9, pp. 1323–1329, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. C. De Lalla, G. Galli, L. Aldrighetti et al., “Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis,” Journal of Immunology, vol. 173, no. 2, pp. 1417–1425, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Gao, S. Radaeva, and O. Park, “Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases,” Journal of Leukocyte Biology, vol. 86, no. 3, pp. 513–528, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Gao, S. Radaeva, and W.-I. Jeong, “Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis,” Expert Review of Gastroenterology & Hepatology, vol. 1, no. 1, pp. 173–180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Gao and S. Radaeva, “Natural killer and natural killer T cells in liver fibrosis,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1832, no. 7, pp. 1061–1069, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Radaeva, R. Sun, B. Jaruga, V. T. Nguyen, Z. Tian, and B. Gao, “Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners,” Gastroenterology, vol. 130, no. 2, pp. 435–452, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Glässner, M. Eisenhardt, B. Krämer et al., “NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner,” Laboratory Investigation, vol. 92, pp. 967–977, 2012. View at Publisher · View at Google Scholar
  36. G. S. Baroni, L. D'Ambrosio, P. Curto et al., “Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis,” Hepatology, vol. 23, no. 5, pp. 1189–1199, 1996. View at Publisher · View at Google Scholar · View at Scopus
  37. W.-I. Jeong, O. Park, S. Radaeva, and B. Gao, “STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity,” Hepatology, vol. 44, no. 6, pp. 1441–1451, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Ramachandran and J. P. Iredale, “Liver fibrosis: a bidirectional model fibrogenesis and resolution,” The Quarterly Journal of Medicine, vol. 105, pp. 813–817, 2012. View at Google Scholar
  39. M. Imamura, T. Ogawa, Y. Sasaguri, K. Chayama, and H. Ueno, “Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats,” Gastroenterology, vol. 128, no. 1, pp. 138–146, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. J. S. Duffield, S. J. Forbes, C. M. Constandinou et al., “Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair,” The Journal of Clinical Investigation, vol. 115, no. 1, pp. 56–65, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. C. Mitchell, D. Couton, J.-P. Couty et al., “Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice,” The American Journal of Pathology, vol. 174, no. 5, pp. 1766–1775, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Heymann, L. Hammerich, D. Storch et al., “Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice,” Hepatology, vol. 55, no. 3, pp. 898–909, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Galastri, E. Zamara, S. Milani et al., “Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis,” Clinical Science, vol. 123, no. 7, pp. 459–471, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. T. A. Wynn and L. Barron, “Macrophages: master regulators of inflammation and fibrosis,” Seminars in Liver Disease, vol. 30, no. 3, pp. 245–257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. S. L. Friedman, “Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver,” Physiological Reviews, vol. 88, no. 1, pp. 125–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. Sunami, F. Leithäuser, S. Gul et al., “Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation,” Hepatology, vol. 56, no. 3, pp. 1117–1128, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. S. L. Friedman, “Mac the knife? Macrophages—the double-edged sword of hepatic fibrosis,” The Journal of Clinical Investigation, vol. 115, no. 1, pp. 29–32, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. J. A. Thomas, C. Pope, D. Wojtacha et al., “Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function,” Hepatology, vol. 53, no. 6, pp. 2003–2015, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. A. M. Elsharkawy, F. Oakley, and D. A. Mann, “The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis,” Apoptosis, vol. 10, no. 5, pp. 927–939, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. R. Fischer, A. Cariers, R. Reinehr, and D. Häussinger, “Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells,” Gastroenterology, vol. 123, no. 3, pp. 845–861, 2002. View at Publisher · View at Google Scholar · View at Scopus
  51. K. R. Karlmark, R. Weiskirchen, H. W. Zimmermann et al., “Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis,” Hepatology, vol. 50, no. 1, pp. 261–274, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. R. Bataller and D. A. Brenner, “Liver fibrosis,” Journal of Clinical Investigation, vol. 115, no. 2, pp. 209–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. N. Muhanna, A. Horani, S. Doron, and R. Safadi, “Lymphocyte-hepatic stellate cell proximity suggests a direct interaction,” Clinical & Experimental Immunology, vol. 148, no. 2, pp. 338–347, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. R. Safadi, M. Ohta, C. E. Alvarez et al., “Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes,” Gastroenterology, vol. 127, no. 3, pp. 870–882, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. O. Viñas, R. Bataller, P. Sancho-Bru et al., “Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation,” Hepatology, vol. 38, no. 4, pp. 919–929, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. N. Muhanna, S. Doron, O. Wald et al., “Activation of hepatic stellate cells after phagocytosis of lymphocytes: a novel pathway of fibrogenesis,” Hepatology, vol. 48, no. 3, pp. 963–977, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. A. M. Gressner and M. G. Bachem, “Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis,” Seminars in Liver Disease, vol. 10, no. 1, pp. 30–46, 1990. View at Publisher · View at Google Scholar · View at Scopus
  58. Z. Shi, A. E. Wakil, and D. C. Rockey, “Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 20, pp. 10663–10668, 1997. View at Publisher · View at Google Scholar · View at Scopus
  59. T. A. Wynn, “Fibrotic disease and the TH1/TH2 paradigm,” Nature Reviews Immunology, vol. 4, no. 8, pp. 583–594, 2004. View at Publisher · View at Google Scholar · View at Scopus
  60. T. I. Novobrantseva, G. R. Majeau, A. Amatucci et al., “Attenuated liver fibrosis in the absence of B cells,” Journal of Clinical Investigation, vol. 115, no. 11, pp. 3072–3082, 2005. View at Publisher · View at Google Scholar · View at Scopus
  61. R. K. Bhogal and C. A. Bona, “B cells: no longer bystanders in liver fibrosis,” The Journal of Clinical Investigation, vol. 115, no. 11, pp. 2962–2965, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. B.-B. Wang, J.-Y. Cheng, H.-H. Gao, Y. Zhang, Z.-N. Chen, and H. Bian, “Hepatic stellate cells in inflammation-fibrosis-carcinoma axis,” Anatomical Record, vol. 293, no. 9, pp. 1492–1496, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. S. L. Friedman, “Mechanisms of hepatic fibrogenesis,” Gastroenterology, vol. 134, no. 6, pp. 1655–1669, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. Y.-J. Liang, J. Luo, Q. Lu et al., “Gene profile of Chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells,” PLoS ONE, vol. 7, no. 8, Article ID e42490, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. K. Bourd-Boittin, L. Basset, D. Bonnier, A. L'Helgoualc'H, M. Samson, and N. Théret, “CX3CL1/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver,” Journal of Cellular and Molecular Medicine, vol. 13, no. 8A, pp. 1526–1535, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. T. Knittel, C. Dinter, D. Kobold et al., “Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair,” The American Journal of Pathology, vol. 154, no. 1, pp. 153–167, 1999. View at Publisher · View at Google Scholar · View at Scopus
  67. J. A. Fallowfield, “Therapeutic targets in liver fibrosis,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 300, no. 5, pp. G709–G715, 2011. View at Publisher · View at Google Scholar · View at Scopus
  68. S. L. Friedman, “Liver fibrosis—from bench to bedside,” Journal of Hepatology, vol. 38, no. 1, pp. S38–S53, 2003. View at Google Scholar · View at Scopus
  69. H. Hayashi and T. Sakai, “Animal models for the study of liver fibrosis: new insights from knockout mouse models,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 300, no. 5, pp. G729–G738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. J. R. Klune, R. Dhupar, J. Cardinal, T. R. Billiar, A. Tsung, and A. Tsung, “HMGB1:Endogenous danger signaling,” Molecular Medicine, vol. 14, no. 7-8, pp. 476–484, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. R. Dhupar, J. R. Klune, J. Evankovich et al., “Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury,” Shock, vol. 35, no. 3, pp. 293–301, 2011. View at Publisher · View at Google Scholar · View at Scopus
  72. G. P. Sims, D. C. Rowe, S. T. Rietdijk, R. Herbst, and A. J. Coyle, “HMGB1 and RAGE in inflammation and cancer,” Annual Review of Immunology, vol. 28, pp. 367–388, 2010. View at Publisher · View at Google Scholar · View at Scopus
  73. C. Wang, H. Nie, K. Li et al., “Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice,” European Journal of Pharmacology, vol. 697, no. 1–3, pp. 152–157, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. C.-T. Tu, Q.-Y. Yao, B.-L. Xu, and S.-C. Zhang, “Curcumin protects against concanavalin a-induced hepatitis in mice through inhibiting the cytoplasmic translocation and expression of high mobility group Box 1,” Inflammation, vol. 36, no. 1, pp. 206–215, 2013. View at Publisher · View at Google Scholar · View at Scopus
  75. M. Ogiku, H. Kono, M. Hara, M. Tsuchiya, and H. Fujii, “Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by kupffer cells after ischemia-reperfusion in rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 339, no. 1, pp. 93–98, 2011. View at Publisher · View at Google Scholar · View at Scopus
  76. N. Yun, J.-W. Kang, and S.-M. Lee, “Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties,” Journal of Nutritional Biochemistry, vol. 23, no. 10, pp. 1249–1255, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. C.-T. Tu, Q.-Y. Yao, B.-L. Xu, J.-Y. Wang, C.-H. Zhou, and S.-C. Zhang, “Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression,” Food and Chemical Toxicology, vol. 50, no. 9, pp. 3343–3351, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. S. L. Deshmane, S. Kremlev, S. Amini, and B. E. Sawaya, “Monocyte chemoattractant protein-1 (MCP-1): an overview,” Journal of Interferon and Cytokine Research, vol. 29, no. 6, pp. 313–325, 2009. View at Publisher · View at Google Scholar · View at Scopus
  79. A. A. Nanji, K. Jokelainen, G. L. Tipoe, A. Rahemtulla, P. Thomas, and A. J. Dannenberg, “Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 284, no. 2, pp. G321–G327, 2003. View at Google Scholar · View at Scopus
  80. I. A. Leclercq, G. C. Farrell, C. Sempoux, A. D. Peña, and Y. Horsmans, “Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice,” Journal of Hepatology, vol. 41, no. 6, pp. 926–934, 2004. View at Publisher · View at Google Scholar · View at Scopus
  81. F. Vizzutti, A. Provenzano, S. Galastri et al., “Curcumin limits the fibrogenic evolution of experimental steatohepatitis,” Laboratory Investigation, vol. 90, no. 1, pp. 104–115, 2010. View at Publisher · View at Google Scholar · View at Scopus
  82. J.-J. Kuo, H.-H. Chang, T.-H. Tsai, and T.-Y. Lee, “Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis,” International Journal of Molecular Medicine, vol. 30, no. 3, pp. 673–679, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. X. Lv, Z. Chen, J. Li et al., “Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress,” Inflammation Research, vol. 59, no. 8, pp. 635–645, 2010. View at Publisher · View at Google Scholar · View at Scopus
  84. Y.-H. Paik, Y. J. Yoon, H. C. Lee et al., “Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats,” Experimental & Molecular Medicine, vol. 43, no. 6, pp. 341–349, 2011. View at Publisher · View at Google Scholar · View at Scopus
  85. Y. H. Oo, S. Shetty, and D. H. Adams, “The role of chemokines in the recruitment of lymphocytes to the liver,” Digestive Diseases, vol. 28, no. 1, pp. 31–44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. C.-T. Tu, B. Han, H.-C. Liu, and S.-C. Zhang, “Curcumin protects mice against Concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression,” Molecular and Cellular Biochemistry, vol. 358, no. 1-2, pp. 53–60, 2011. View at Publisher · View at Google Scholar · View at Scopus
  87. L. Cao, Y. Zou, J. Zhu, X. Fan, and J. Li, “Ginsenoside Rg1 attenuates concanavalin A-induced hepatitis in mice through inhibition of cytokine secretion and lymphocyte infiltration,” Molecular and Cellular Biochemistry, vol. 380, no. 1-2, pp. 203–210, 2013. View at Publisher · View at Google Scholar · View at Scopus
  88. Y.-L. Lin, Y.-C. Hsu, Y.-T. Chiu, and Y.-T. Huang, “Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats,” Phytotherapy Research, vol. 22, no. 1, pp. 69–76, 2008. View at Publisher · View at Google Scholar · View at Scopus
  89. Y. Xu, D. Feng, Y. Wang, S. Lin, and L. Xu, “Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-κB and IFN-γ/STAT1 pathways,” Journal of Clinical Immunology, vol. 28, no. 5, pp. 512–519, 2008. View at Publisher · View at Google Scholar · View at Scopus
  90. R. Bruck, M. Ashkenazi, S. Weiss et al., “Prevention of liver cirrhosis in rats by curcumin,” Liver International, vol. 27, no. 3, pp. 373–383, 2007. View at Publisher · View at Google Scholar · View at Scopus
  91. C.-T. Tu, B. Han, Q.-Y. Yao, Y.-A. Zhang, H.-C. Liu, and S.-C. Zhang, “Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression,” International Immunopharmacology, vol. 12, no. 1, pp. 151–157, 2012. View at Publisher · View at Google Scholar · View at Scopus
  92. N. Tsuruoka, K. Abe, K. Wake et al., “Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice,” Inflammation Research, vol. 58, no. 9, pp. 593–599, 2009. View at Publisher · View at Google Scholar · View at Scopus
  93. A. K. Singh, H. Mani, P. Seth et al., “Picroliv preconditioning protects the rat liver against ischemia—reperfusion injury,” European Journal of Pharmacology, vol. 395, no. 3, pp. 229–239, 2000. View at Publisher · View at Google Scholar · View at Scopus
  94. J.-F. Ye, H. Zhu, Z.-F. Zhou et al., “Protective mechanism of andrographolide against carbon tetrachloride- induced acute liver injury in mice,” Biological and Pharmaceutical Bulletin, vol. 34, no. 11, pp. 1666–1670, 2011. View at Publisher · View at Google Scholar · View at Scopus
  95. M.-E. Wang, Y.-C. Chen, I.-S. Chen, S.-C. Hsieh, S.-S. Chen, and C.-H. Chiu, “Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes,” Journal of Nutritional Biochemistry, vol. 23, no. 10, pp. 1352–1366, 2012. View at Publisher · View at Google Scholar · View at Scopus
  96. D.-H. Jeong, G.-P. Lee, W.-I. Jeong et al., “Alterations of mast cells and TGF-β1 on the silymarin treatment for CCI4-induced hepatic fibrosis,” World Journal of Gastroenterology, vol. 11, no. 8, pp. 1141–1148, 2005. View at Publisher · View at Google Scholar · View at Scopus
  97. N. M. El-Lakkany, O. A. Hammam, W. H. El-Maadawy, A. A. Badawy, A. A. Ain-Shoka, and F. A. Ebeid, “Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the Schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis,” Parasites and Vectors, vol. 5, no. 1, article 9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  98. G. Pener, L. Kabasakal, M. Yüksel, N. Gedik, and Ý. Alican, “Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment,” World Journal of Gastroenterology, vol. 11, no. 35, pp. 5444–5449, 2005. View at Google Scholar · View at Scopus
  99. J.-G. Liu, Y.-R. Ding, and S.-L. Yang, “Effect of salvianolic acid B on CD14 expression in rats with liver fibrosis,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 31, no. 4, pp. 547–551, 2011. View at Google Scholar · View at Scopus
  100. C.-T. Tu, J. Li, F.-P. Wang, L. Li, J.-Y. Wang, and W. Jiang, “Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway,” International Immunopharmacology, vol. 14, no. 4, pp. 410–421, 2012. View at Publisher · View at Google Scholar · View at Scopus
  101. D. N. Roy, G. Sen, K. D. Chowdhury, and T. Biswas, “Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with D-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis,” Toxicology and Applied Pharmacology, vol. 250, no. 1, pp. 54–68, 2011. View at Publisher · View at Google Scholar · View at Scopus
  102. S. G. Shim, D. W. Jun, E. K. Kim et al., “Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model,” Journal of Gastroenterology and Hepatology, vol. 28, no. 12, pp. 1877–1884, 2013. View at Publisher · View at Google Scholar · View at Scopus
  103. X.-Y. Qin, T. Li, L. Yan, Q.-S. Liu, and Y. Tian, “Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines,” Immunopharmacology and Immunotoxicology, vol. 32, no. 1, pp. 51–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  104. T. Lawrence, “The nuclear factor NF-kappaB pathway in inflammation,” Cold Spring Harbor Perspectives in Biology, vol. 1, no. 6, Article ID a001651, 2009. View at Publisher · View at Google Scholar · View at Scopus
  105. X.-G. Sun, X.-Q. Fu, H.-B. Cai et al., “Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice,” Phytotherapy Research, vol. 25, no. 7, pp. 1087–1094, 2011. View at Publisher · View at Google Scholar · View at Scopus
  106. J.-Y. Wan, X. Gong, L. Zhang, H.-Z. Li, Y.-F. Zhou, and Q.-X. Zhou, “Protective effect of baicalin against Lipopolysaccharide/d-galactosamine-induced liver injury in mice by up-regulation of Heme oxygenase-1,” European Journal of Pharmacology, vol. 587, no. 1–3, pp. 302–308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  107. S.-J. Kim, Y.-J. Moon, and S.-M. Lee, “Protective effects of baicalin against ischemia/reperfusion injury in rat liver,” Journal of Natural Products, vol. 73, no. 12, pp. 2003–2008, 2010. View at Publisher · View at Google Scholar · View at Scopus
  108. B. Shen, J. Yu, S. Wang et al., “Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo,” Hepatology, vol. 47, no. 2, pp. 473–483, 2008. View at Publisher · View at Google Scholar · View at Scopus
  109. K. S. Kang, H. Y. Kim, N. Yamabe, J. H. Park, and T. Yokozawa, “Preventive effect of 20(S)-ginsenoside Rg3 against lipopolysaccharide-induced hepatic and renal injury in rats,” Free Radical Research, vol. 41, no. 10, pp. 1181–1188, 2007. View at Publisher · View at Google Scholar · View at Scopus
  110. S.-J. Wu, K.-W. Tam, Y.-H. Tsai, C.-C. Chang, and J. C.-J. Chao, “Curcumin and saikosaponin A inhibit chemical-induced liver inflammation and fibrosis in rats,” The American Journal of Chinese Medicine, vol. 38, no. 1, pp. 99–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  111. A. R. Bassiouny, A. Zaky, F. Fawky, and K. M. Kandeel, “Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats,” Annals of Hepatology, vol. 10, no. 4, pp. 516–530, 2011. View at Google Scholar · View at Scopus
  112. S.-Q. Liu, J.-P. Yu, L. He, H.-G. Yu, and H.-S. Luo, “Effects of nuclear factor kappaB and transforming growth factor beta1 in the anti-liver fibrosis process using Ginkgo biloba extract,” Zhonghua Gan Zang Bing Za Zhi, vol. 13, no. 12, pp. 903–907, 2005. View at Google Scholar · View at Scopus
  113. Z.-Y. Zhou, S.-Q. Tang, Y.-M. Zhou, H.-S. Luo, and X. Liu, “Antioxidant and hepatoprotective effects of extract of ginkgo biloba in rats of non-alcoholic steatohepatitis,” Saudi Medical Journal, vol. 31, no. 10, pp. 1114–1118, 2010. View at Google Scholar · View at Scopus
  114. R. Wang, X.-Y. Yu, Z.-Y. Guo, Y.-J. Wang, Y. Wu, and Y.-F. Yuan, “Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling,” Journal of Ethnopharmacology, vol. 144, no. 3, pp. 592–598, 2012. View at Publisher · View at Google Scholar · View at Scopus
  115. J.-Y. Wang, J.-S. Guo, H. Li, S.-L. Liu, and M. A. Zern, “Inhibitory effect of glycyrrhizin on NF-κB binding activity in CCl(4-) plus ethanol-induced liver cirrhosis in rats,” Liver, vol. 18, no. 3, pp. 180–185, 1998. View at Google Scholar · View at Scopus
  116. S.-J. Kim and S.-M. Lee, “Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition,” Toxicology and Applied Pharmacology, vol. 258, no. 1, pp. 43–50, 2012. View at Publisher · View at Google Scholar · View at Scopus
  117. S.-S. Dang, B.-F. Wang, Y.-A. Cheng, P. Song, Z.-G. Liu, and Z.-F. Li, “Inhibitory effects of saikosaponin-D on CCl4-induced hepatic fibrogenesis in rats,” World Journal of Gastroenterology, vol. 13, no. 4, pp. 557–563, 2007. View at Publisher · View at Google Scholar · View at Scopus
  118. H. Shi, L. Dong, J. Jiang et al., “Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway,” Toxicology, vol. 303, pp. 107–114, 2013. View at Publisher · View at Google Scholar · View at Scopus
  119. R. van den Berg, G. R. M. M. Haenen, H. van den Berg, and A. Bast, “Transcription factor NF-κB as a potential biomarker for oxidative stress,” British Journal of Nutrition, vol. 86, pp. S121–S127, 2001. View at Publisher · View at Google Scholar · View at Scopus
  120. R. F. Schwabe, E. Seki, and D. A. Brenner, “Toll-like receptor signaling in the liver,” Gastroenterology, vol. 130, no. 6, pp. 1886–1900, 2006. View at Publisher · View at Google Scholar · View at Scopus
  121. A. M. Piccinini and K. S. Midwood, “DAMPening inflammation by modulating TLR signalling,” Mediators of Inflammation, vol. 2010, Article ID 672395, 21 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  122. F.-P. Wang, L. Li, J. Li, J.-Y. Wang, L.-Y. Wang, and W. Jiang, “High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3K/Akt and JNK,” PLoS ONE, vol. 8, no. 5, Article ID e64373, 2013. View at Publisher · View at Google Scholar · View at Scopus
  123. Q. Wang, R. Dziarski, C. J. Kirschning, M. Muzio, and D. Gupta, “Micrococci and peptidoglycan activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-kappaB signal transduction pathway that induces transcription of interleukin-8,” Infection and Immunity, vol. 69, no. 4, pp. 2270–2276, 2001. View at Google Scholar
  124. A. Paine, B. Eiz-Vesper, R. Blasczyk, and S. Immenschuh, “Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential,” Biochemical Pharmacology, vol. 80, no. 12, pp. 1895–1903, 2010. View at Publisher · View at Google Scholar · View at Scopus
  125. M. L. Ferrándiz and I. Devesa, “Inducers of heme oxygenase-1,” Current Pharmaceutical Design, vol. 14, no. 5, pp. 473–486, 2008. View at Publisher · View at Google Scholar · View at Scopus
  126. K. Tsoyi, Y. L. Tae, S. L. Young et al., “Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo,” Molecular Pharmacology, vol. 76, no. 1, pp. 173–182, 2009. View at Publisher · View at Google Scholar · View at Scopus
  127. R.-H. Shih and C.-M. Yang, “Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells,” Journal of Neuroinflammation, vol. 7, article 86, 2010. View at Publisher · View at Google Scholar · View at Scopus
  128. C.-H. Lee, S.-W. Park, Y. S. Kim et al., “Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice,” Biological and Pharmaceutical Bulletin, vol. 30, no. 10, pp. 1898–1904, 2007. View at Publisher · View at Google Scholar · View at Scopus
  129. S.-W. Park, C.-H. Lee, S. K. Yeong et al., “Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice,” Journal of Pharmacological Sciences, vol. 106, no. 1, pp. 136–143, 2008. View at Publisher · View at Google Scholar · View at Scopus
  130. M.-K. Tsai, Y.-L. Lin, and Y.-T. Huang, “Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats,” Toxicology and Applied Pharmacology, vol. 242, no. 2, pp. 155–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  131. M. Kim, S.-G. Yang, J. M. Kim, J.-W. Lee, Y. S. Kim, and J. I. Lee, “Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: analysis of isolated hepatic stellate cells,” International Journal of Molecular Medicine, vol. 30, no. 3, pp. 473–479, 2012. View at Publisher · View at Google Scholar · View at Scopus
  132. Z. Song, I. Deaciuc, M. Song et al., “Silymarin protects against acute ethanol-induced hepatotoxicity in mice,” Alcoholism: Clinical and Experimental Research, vol. 30, no. 3, pp. 407–413, 2006. View at Publisher · View at Google Scholar · View at Scopus
  133. R. M. Chávez-Morales, F. Jaramillo-Juárez, F. A. Posadas Del Río, M. A. Reyes-Romero, M. L. Rodríguez-Vázquez, and M. C. Martínez-Saldaña, “Protective effect of Ginkgo biloba extract on liver damage by a single dose of CCl4 in male rats,” Human and Experimental Toxicology, vol. 30, no. 3, pp. 209–216, 2011. View at Publisher · View at Google Scholar · View at Scopus
  134. Z.-M. Wu, T. Wen, Y.-F. Tan, Y. Liu, F. Ren, and H. Wu, “Effects of salvianolic acid A on oxidative stress and liver injury induced by carbon tetrachloride in rats,” Basic & Clinical Pharmacology & Toxicology, vol. 100, no. 2, pp. 115–120, 2007. View at Publisher · View at Google Scholar · View at Scopus
  135. M. Abe, F. Akbar, A. Hasebe, N. Horiike, and M. Onji, “Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis,” Journal of Gastroenterology, vol. 38, no. 10, pp. 962–967, 2003. View at Publisher · View at Google Scholar · View at Scopus
  136. T. Yoshida, K. Abe, T. Ikeda et al., “Inhibitory effect of glycyrrhizin on lipopolysaccharide and d-galactosamine-induced mouse liver injury,” European Journal of Pharmacology, vol. 576, no. 1–3, pp. 136–142, 2007. View at Publisher · View at Google Scholar · View at Scopus
  137. L.-L. Liu, L.-K. Gong, H. Wang et al., “Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis,” Liver International, vol. 27, no. 4, pp. 582–591, 2007. View at Publisher · View at Google Scholar · View at Scopus
  138. P. Pramyothin, P. Samosorn, S. Poungshompoo, and C. Chaichantipyuth, “The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury,” Journal of Ethnopharmacology, vol. 107, no. 3, pp. 361–364, 2006. View at Publisher · View at Google Scholar · View at Scopus
  139. V. Suresh and V. V. Asha, “Preventive effect of ethanol extract of Phyllanthus rheedii Wight. on d-galactosamine induced hepatic damage in Wistar rats,” Journal of Ethnopharmacology, vol. 116, no. 3, pp. 447–453, 2008. View at Publisher · View at Google Scholar · View at Scopus
  140. P. Pramyothin, C. Ngamtin, S. Poungshompoo, and C. Chaichantipyuth, “Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies,” Journal of Ethnopharmacology, vol. 114, no. 2, pp. 169–173, 2007. View at Publisher · View at Google Scholar · View at Scopus
  141. R. Domitrović, H. Jakovac, and G. Blagojević, “Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl4-intoxicated mice,” Toxicology, vol. 280, no. 1-2, pp. 33–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  142. D. H. Kim, J. H. Chung, J. S. Yoon et al., “Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264.7 cells and mouse liver,” Journal of Ginseng Research, vol. 37, no. 1, pp. 54–63, 2013. View at Publisher · View at Google Scholar · View at Scopus
  143. I. Akashi, K. Kagami, T. Hirano, and K. Oka, “Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats,” Journal of Pharmacy and Pharmacology, vol. 61, no. 4, pp. 473–478, 2009. View at Publisher · View at Google Scholar · View at Scopus
  144. Y. Fu, S. Zheng, J. Lin, J. Ryerse, and A. Chen, “Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation,” Molecular Pharmacology, vol. 73, no. 2, pp. 399–409, 2008. View at Publisher · View at Google Scholar · View at Scopus
  145. S. Bisht, M. A. Khan, M. Bekhit et al., “A polymeric nanoparticle formulation of curcumin (NanoCurc) ameliorates CCl 4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation,” Laboratory Investigation, vol. 91, no. 9, pp. 1383–1395, 2011. View at Publisher · View at Google Scholar · View at Scopus
  146. G. Yuan, Z. Gong, J. Li, and X. Li, “Ginkgo biloba extract protects against alcohol-induced liver injury in rats,” Phytotherapy Research, vol. 21, no. 3, pp. 234–238, 2007. View at Publisher · View at Google Scholar · View at Scopus
  147. H. Wang, X.-P. Chen, and F.-Z. Qiu, “Salviae miltiorrhizae ameliorates cirrhosis and portal hypertension by inhibiting nitric oxide in cirrhotic rats,” Hepatobiliary and Pancreatic Diseases International, vol. 2, no. 3, pp. 391–396, 2003. View at Google Scholar · View at Scopus
  148. Y. Zhang, Y. Xie, Y. Gao et al., “Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza,” Journal of Ethnopharmacology, vol. 148, no. 2, pp. 671–681, 2013. View at Publisher · View at Google Scholar · View at Scopus
  149. X.-D. Peng, L.-L. Dai, C.-Q. Huang, C.-M. He, and L.-J. Chen, “Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis,” World Journal of Gastroenterology, vol. 15, no. 37, pp. 4720–4725, 2009. View at Publisher · View at Google Scholar · View at Scopus
  150. R. Domitrović, H. Jakovac, V. V. Marchesi, and B. Blažeković, “Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl4-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression,” Journal of Medicinal Food, vol. 16, no. 6, pp. 518–528, 2013. View at Publisher · View at Google Scholar · View at Scopus
  151. X.-D. Peng, L.-L. Dai, C.-Q. Huang, C.-M. He, B. Yang, and L.-J. Chen, “Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis,” Biochemical and Biophysical Research Communications, vol. 388, no. 1, pp. 31–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  152. T.-Y. Lee, K.-C. Lee, and H.-H. Chang, “Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis,” Apoptosis, vol. 15, no. 8, pp. 904–914, 2010. View at Publisher · View at Google Scholar · View at Scopus
  153. J.-W. Shin, J.-H. Wang, J.-K. Kang, and C.-G. Son, “Experimental evidence for the protective effects of coffee against liver fibrosis in SD rats,” Journal of the Science of Food and Agriculture, vol. 90, no. 3, pp. 450–455, 2010. View at Publisher · View at Google Scholar · View at Scopus
  154. P. Vitaglione, F. Morisco, G. Mazzone et al., “Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins,” Hepatology, vol. 52, no. 5, pp. 1652–1661, 2010. View at Publisher · View at Google Scholar · View at Scopus