Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model

Figure 8

Protein levels of (a) IL-6, (b) IL-17, (c) IL-4, (d) IFN-γ, (e) TNF-α, and (f) IL-10 in plasma in a murine model of ethanol exposition for 2 weeks, surgery, and pulmonary infection. Protein levels of indicated cytokines were analyzed by cytometric bead array (CBA) and given as pg/ml plasma of ethanol-treated (ETOH) and saline-treated controls (NaCl) at 24 hours or 48 hours after pulmonary infection with Klebsiella pneumoniae. when compared to time- and treatment-matched control (infection-dependent effects); when comparing 24 hours to 48 hours (time-dependent effects); data are presented as mean ± SEM, Mann–Whitney U test ( each group). n.s.: not significant. IL: interleukin; TNF-α: tumor necrosis factor; IFN-γ: interferon gamma; ETOH: ethanol treatment; K. pneumoniae: pulmonary infection with Klebsiella pneumoniae.

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