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International Journal of Inflammation
Volume 2017 (2017), Article ID 3406215, 17 pages
Review Article

From Inflammation to Current and Alternative Therapies Involved in Wound Healing

1Physiological Sciences Department, Federal University of Maranhão, São Luís, MA, Brazil
2School of Medicine, Emergency Medicine Department, University of São Paulo, São Paulo, SP, Brazil

Correspondence should be addressed to Wermerson Assunção Barroso

Received 28 March 2017; Revised 1 June 2017; Accepted 6 June 2017; Published 25 July 2017

Academic Editor: B. L. Slomiany

Copyright © 2017 Mariana Barreto Serra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency. Finally, we will discuss the current therapeutic interventions in the wounds treatment, and the alternative therapies used as promising results in the development of new products with healing potential.