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International Journal of Inflammation
Volume 2017 (2017), Article ID 3495293, 6 pages
Research Article

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis

Federal State Budget Institution “Bakulev National Scientific and Practical Center for Cardiovascular Surgery” of the Ministry of Healthcare of the Russian Federation (Bakulev NSPCCS), Moscow, Russia

Correspondence should be addressed to Michael Yaroustovsky

Received 31 January 2017; Revised 20 February 2017; Accepted 26 March 2017; Published 12 April 2017

Academic Editor: B. L. Slomiany

Copyright © 2017 Michael Yaroustovsky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin. Results. 83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (). Conclusions. EAA results should be interpreted with the level of neutrophil response. “Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.