Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients

Figure 4

Intestinal mucosa of Crohn’s disease patients shows inflammation driven by NF-KB. Higher SOCS3 protein expression counterbalances the STAT1 activation. Western blot analysis of pIκB/IκB ratio (a), pSTAT1 (b), and SOCS3 (d) in intestinal mucosa of CD patients (ICD Group) compared to controls (IC Group). mRNA levels (qRT-PCR) of STAT1 (c) in intestinal mucosa of CD patients (ICD Group) compared to controls (IC Group). Each band represents one patient. For ICD, ; for IC, ;  ,  , and versus control. ASU: arbitrary scanning unit; TA: transcription amount.

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