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International Journal of Inflammation
Volume 2017, Article ID 8608716, 7 pages
Research Article

High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet’s Disease

1Department of Rheumatology, University Hospital Limerick, Limerick, Ireland
2Graduate Entry Medical School, University of Limerick, Limerick, Ireland
3Health Research Institute, University of Limerick, Ireland
4Department of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia
5Department of Mathematics and Statistics, La Trobe University, Melbourne, VIC, Australia
6Department of Nephrology, University Hospital Limerick, Limerick, Ireland

Correspondence should be addressed to Fahd Adeeb; moc.oohay@beeda_dhaf

Received 16 February 2017; Revised 1 May 2017; Accepted 9 May 2017; Published 4 June 2017

Academic Editor: Jian-Dong Li

Copyright © 2017 Fahd Adeeb et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1 : 5 ratio for age, sex, and the month of the year. 25(OH)D levels <20 nmol/L were classified as deficient while levels between 20 and 40 nmol/L were classified as insufficient. Differences between groups were assessed using Mann–Whitney test and associations between cases and controls were expressed as odds ratios and 95% confidence intervals. Nineteen patients with BD were compared with 95 controls matched by age, sex, and month of blood draw. 25(OH)D levels were significantly higher in patients in BD than in matched controls (median values: 45 nmol/L versus 22 nmol/L, ) and tended to be lower in patients with active disease than in those without (median values: 35 nmol/L (IQR: 22.75–47.25 nm/L) versus 50 nmol/L (IQR: 35–67 nmol/L), ). Compared to controls, patients with BD were significantly less likely to have 25(OH)D deficiency or insufficiency (OR: 0.09, 95% CI: 0.03–0.28, ). Our findings suggest a possible role for 25(OH)D in modifying the inflammatory response in BD and uncover a potential opportunity to assess whether correction of Vit D deficiency confers protective benefits.