International Journal of Inflammation / 2018 / Article / Tab 2

Research Article

Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population

Table 2

Serum concentrations [median (25th–75th percentile) pg/ml] of the eight cytokines measured in tobacco smokers with chronic obstructive pulmonary disease (TS-COPD) and TS CONTROL subjects. p<0.05 is considered as significant.

CytokinesTS-COPD (n=30)TS-CONTROL (n=20)p value
(pg/ml)(pg/ml)

GM-CSF69.64 (46.67 - 97.48)36.78 (30.07 - 53.88)0.014

IFN-51.06 (17 - 84.86)11.7 (3.18 - 32.81)0.017

IL-22.29 (2.29 - 2.73)2.29 (2.29 – 2.29)0.08

IL-49.09 (1.8 - 19.9)1.8 (1.8 - 4.46)0.024

IL-614.42 (7.76 - 21.18)13.04 (11.65-21.34)0.68

IL-814.22 (8.96 - 21.23)22.7 (9.75 – 35.18)0.40

IL-103.4 (3.4 - 6.65)3.6 (2.19 - 6.4)0.70

TNF-20.68 (5.5 – 29.26)3.5 (3.5 - 4.5)<0.001

GM-CSF: granular macrophage colony stimulating factor; IFN-: interferon gamma; IL: interleukin; TNF-: tumor necrosis factor alpha.

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