Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia

Table 2

Subpopulation of lymphocytes in the peripheral blood of tolerant- (T) and susceptible- (S) to-hypoxia Wistar rats in 3, 6, and 24 hours after LPS injection. Data are presented as median (25%, 75%); the statistical significance of differences (p) between tolerant and susceptible rats is determined by the Mann-Whitney U test and between different time points after LPS injection by the Kruskal-Wallis method ( = 5 in each group).

Lymphocyte subpopulation, 10^6/ml	Group	Control group^1	LPS injection			p(p<0.05)
			3 h^2	6 h^3	24 h^4
Т-lymphocytes; (CD3+)	T	3.5	2.7	1.7	6.0	0.02^2-4
		(2.7–4.3)	(2.1–2.8)	(1.2–2.6)	(5.4–6.2)	0.04^3-4
	S	7.0	2.3	1.9	4.6	0.004^1-3
		(4.8–7.7)	(2.2–3.2)	(1.7–2.2)	(3.9–5.2)
	p	0.09	0.75	0.81	0.03
Т-helper cells; (CD3+CD4+)	T	2.2	1.1	0.4	2.7	0.005^3-4
		(1.6–2.4)	(1.0–1.1)	(0.3–0.5)	(1.9–3.1)
	S	1.8	1.1	0.4	2.1	0.02^1-3
		(1.6–2.1)	(1.0–1.3)	(0.3–0.5)	(1.6–2.3)	0.008^3-4
	p	0.80	0.60	0.62	0.31
Cytotoxic; Т-lymphocytes; (CD3+CD8+)	T	1.2	1.5	1.3	3.0
		(1.0–1.8)	(1.0–1.7)	(0.8–2.0)	(2.5–4.1)
	S	5.6	1.2	1.4	2.4	0.04^1-2
		(3.0–5.9)	(1.2–1.2)	(0.9–1.7)	(1.5–3.0)
	p	0.03	0.75	0.62	0.19
Regulatory; Т-cells; (CD4+CD25+; Foxp3+)	T	0.05	0.009	0.003	0.05	0.04^1-3
		(0.03–0.06)	(0.006–0.01)	(0.002–0.005)	(0.03–0.09)	0.04^2-4
						0.003^3-4
	S	0.05	0.01	0.006	0.03	0.009^1-3
		(0.02–0.05)	(0.007–0.01)	(0.004–0.006)	(0.01–0.05)	0.04^3-4
	p	0.81	0.75	0.14	0.24
NK (CD314+)	T	0.8	0.7	1.4	2.6	0.006^2-4
		(0.8–1.2)	(0.6–1.2)	(1.3–2.1)	(2.1–3.5)
	S	2.2	0.5	1.5	2.0	0.01^1-2
		(1.7–2.5)	(0.3–0.6)	(1.0–1.7)	(1.2–2.0)	0.04^2-4
	p	0.03	0.09	0.65	0.04
В-lymphocytes; (CD45+)	T	2.3	0.6	0.7	2.6	0.009^2-4
		(1.8–2.6)	(0.3–0.9)	(0.3–0.8)	(2.1–3.8)	0.02^3-4
	S	2.2	0.3	0.5	2.3	0.04^1-2
		(1.9–2.9)	(0.2–0.5)	(0.4–0.5)	(2.2–2.7)	0.03^2-4
	p	0.81	0.06	0.65	0.88