Effects of Albumin Infusion on Serum Levels of Albumin, Proinflammatory Cytokines (TNF-α, IL-1, and IL-6), CRP, and MMP-8; Tissue Expression of EGRF, ERK1, ERK2, TGF-β, Collagen, and MMP-8; and Wound Healing in Sprague Dawley Rats

Table 2

Comparison of mean albumin, TNF-α, IL-1, IL-6, CRP, and MMP-8 for the hypoalbuminemia + albumin infusion (B), hypoalbuminemia + normal protein diet (C), and hypoalbuminemia groups (D and E).

Variable	Group (mean ± SD)					HT
	B	C	D and E (hypoalbuminemia)	Total
Albumin	5.48 ± 1.30	4.03 ± 0.99	2.30 ± 1.38	3.93 ± 1.38	0.01	0.01
TNF-α	2.92 ± 1.98	4.32 ± 1.52	9.29 ± 1.43	5.84 ± 2.96	0.01
IL-1	19.81 ± 9.76	21.79 ± 7.46	46.09 ± 6.94	29.23 ± 14.48	0.01
IL-6	20.03 ± 2.60	19.96 ± 5.66	21.22 ± 4.105	20.40 ± 4.00	0.87
MMP-8	75.34 ± 11.33	74.86 ± 22.36	79.99 ± 16.28	76.73 ± 16.15	0.87
CRP	19.65 ± 9.97	21.67 ± 7.65	46.26 ± 6.84	29.19 ± 14.68	0.01

HT: Hotelling’s trace.