Effects of Albumin Infusion on Serum Levels of Albumin, Proinflammatory Cytokines (TNF-α, IL-1, and IL-6), CRP, and MMP-8; Tissue Expression of EGRF, ERK1, ERK2, TGF-β, Collagen, and MMP-8; and Wound Healing in Sprague Dawley Rats

Table 4

Comparison of mean TNF-α, IL-1, IL-6, MMP-8, and CRP for postoperative (A) control, (B) hypoalbuminemia + preoperative albumin infusion, (C) hypoalbuminemia + normal protein diet, (D) hypoalbuminemia + postoperative albumin infusion, and hypoalbuminemia (E) groups.

Variable	Group (mean ± SD)							HT
	A	B	C	D	E	Total
TNF-α	2.77 ± 0.78	6.27 ± 1.12	5.84 ± 1.14	6.94 ± 1.64	10.54 ± 0.57	6.46 ± 2.74	0.01	0.01
IL-1	13.88 ± 3.81	31.66 ± 5.36	29.27 ± 5.47	34.52 ± 8.09	52.40 ± 2.63	32.35 ± 13.50	0.01
IL-6	18.33 ± 8.17	15.23 ± 4.44	31.09 ± 33.47	18.69 ± 10.57	13.30 ± 5.47	19.33 ± 16.34	0.50
MMP-8	68.76 ± 31.89	66.19 ± 20.72	60.38 ± 27.43	69.90 ± 41.08	49.33 ± 25.35	62.91 ± 28.53	0.81
CRP	13.62 ± 3.95	31.53 ± 5.64	29.45 ± 5.55	35.27 ± 7.63	52.89 ± 2.80	32.43 ± 13.55	0.01

HT: Hotelling’s trace.