Effects of Albumin Infusion on Serum Levels of Albumin, Proinflammatory Cytokines (TNF-α, IL-1, and IL-6), CRP, and MMP-8; Tissue Expression of EGRF, ERK1, ERK2, TGF-β, Collagen, and MMP-8; and Wound Healing in Sprague Dawley Rats

Table 5

Comparison of mean EGFR, ERK1, ERK2, TGF-β, collagen, and MMP-8 for control (A), hypoalbuminemia + presurgical albumin infusion (B), hypoalbuminemia + normal protein diet (C), hypoalbuminemia + infusion postoperative albumin (D), and hypoalbuminemia (E) on days 1, 3, 5, and 7 after surgery.

Variable	Day	Group (mean ± SD)							HT
		A	B	C	D	E	Total
EGFR	1	11.60 ± 3.64	13.00 ± 1.58	11.40 ± 2.19	11.40 ± 2.30	9.20 ± 1.48	11.32 ± 2.49	0.20	0.01
ERK1		14.80 ± 4.32	12.60 ± 2.60	12.40 ± 2.30	11.20 ± 2.38	9.60 ± 1.14	12.12 ± 3.06	0.81
ERK2		11.20 ± 1.92	9.40 ± 1.82	10.00 ± 2.45	9.60 ± 1.82	9.60 ± 1.52	9.96 ± 1.88	0.59
TGF-β		17.80 ± 6.26	22.60 ± 2.61	20.00 ± 5.70	11.80 ± 1.92	22.40 ± 2.88	18.92 ± 5.61	0.01
Collagen		13.40 ± 3.13	12.80 ± 2.59	13.80 ± 2.77	12.60 ± 2.80	13.40 ± 3.43	13.20 ± 2.73	0.96
MMP-8		11.40 ± 3.97	12.40 ± 2.51	11.20 ± 3.35	11.40 ± 1.67	10.00 ± 1.58	11.28 ± 2.65	0.75
EGFR	3	15.20 ± 5.16	14.80 ± 1.92	16.8 ± 4.55	14.80 ± 3.83	5.20 ± 3.27	13.36 ± 3.54	0.01	0.01
ERK1		10.40 ± 2.30	10.80 ± 2.39	8.80 ± 3.56	11.20 ± 2.49	5.60 ± 2.40	9.36 ± 3.21	0.02
ERK2		13.60 ± 2.07	16.20 ± 1.30	17.20 ± 1.92	9.60 ± 1.14	9.00 ± 1.87	13.12 ± 3.75	0.01
TGF-β		15.00 ± 2.91	15.80 ± 3.56	16.60 ± 3.65	13.60 ± 3.05	11.20 ± 2.39	14.44 ± 3.46	0.97
Collagen		11.40 ± 2.30	12.40 ± 3.29	15.40 ± 3.36	10.60 ± 1.14	9.20 ± 1.30	11.80 ± 3.09	0.01
MMP-8		11.80 ± 2.39	12.40 ± 2.07	10.60 ± 2.51	10.20 ± 1.30	14.60 ± 2.79	11.92 ± 2.61	0.05
EGFR	5	8.20 ± 1.64	18.60 ± 3.29	20.80 ± 2.59	15.40 ± 4.33	4.00 ± 1.87	13.4 ± 7.00	0.01	0.01
ERK1		10.20 ± 1.92	15.4 ± 3.78	18.00 ± 3.16	14.20 ± 3.49	5.00 ± 2.55	12.56 ± 5.41	0.01∗
ERK2		14.20 ± 4.32	14.60 ± 3.58	23.00 ± 3.67	18.80 ± 4.66	7.20 ± 2.17	15.56 ± 6.38	0.01
TGF		20.80 ± 1.48	13.80 ± 3.35	20.20 ± 2.39	21.20 ± 1.30	6.40 ± 2.30	16.48 ± 6.20	0.01
Collagen		14.00 ± 2.91	20.00 ± 1.58	22.60 ± 2.70	17.80 ± 5.63	7.20 ± 2.68	16.32 ± 6.28	0.01
MMP-8		4.60 ± 2.70	11.20 ± 2.17	7.60 ± 2.70	9.80 ± 2.17	21.60 ± 1.95	10.96 ± 6.27	0.01
EGFR	7	24.80 ± 3.27	25.40 ± 2.96	25.20 ± 4.32	19.80 ± 2.86	4.20 ± 1.79	19.88 ± 8.76	0.01	0.01
ERK1		23.00 ± 3.53	24.40 ± 2.70	23.00 ± 3.00	18.60 ± 1.95	3.40 ± 1.52	18.48 ± 8.30	0.01
ERK2		15.60 ± 4.83	24.00 ± 2.35	23.80 ± 3.70	19.00 ± 5.66	3.20 ± 1.30	17.12 ± 8.57	0.01
TGF-β		15.60 ± 1.95	26.40 ± 3.36	24.60 ± 3.65	22.60 ± 3.51	6.60 ± 2.07	19.16 ± 7.91	0.01
Collagen		23.40 ± 3.65	25.40 ± 1.67	25.60 ± 2.51	19.60 ± 1.14	4.60 ± 2.07	19.72 ± 8.31	0.01
MMP-8		11.00 ± 2.35	7.800 ± 1.30	8.00 ± 2.24	28.00 ± 2.74	28.00 ± 2.74	16.56 ± 9.84	0.01

HT: Hotelling’s trace.