Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity

Table 3

Histopathological results.

	Renal capsule	Glomeruli	BS	Tubular lining	Tubular lumen	Brush border	Interstitium	Medulla
Group I	0	0	0	0	0	0	0	0
Group II	+	++	+	++	++	++	++	++
Group III	0	++	+	+	++	+	++	+
Group IV	0	+	+	+	++	+	+	+
Group V	0	0	0	+	++	+	+	+

Renal capsule: 0: average +: partially detached ++: completely detached. Glomeruli (G): 0: average +: small-sized/congested ++: atrophied. Bowman’s spaces (BS): 0: average + : widened/dilated ++: obliterated. Tubular lining: 0: average +: edematous/apoptotic ++: necrotic. Tubular lumen: 0: free +: cellular debris ++: hyaline casts. Brush border: 0: preserved +: partial loss ++: complete loss. Interstitium: 0: average +: mildly dilated BV ++: markedly dilated BV. Medulla: 0: average +: cellular debris/ hyaline casts ++: atrophied lining.