Research Article

Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract

Figure 6

A proposed mechanism of B. davidii against C. acnes-induced skin inflammation. B. davidii inhibits the inflammation by suppressing the NF-κB and MAPK signaling pathways, which are activated by TLR-2, leading to the reduced expression of the proinflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8.