Inhibition of Proinflammatory Cytokines in Cutibacterium acnes-Induced Inflammation in HaCaT Cells by Using Buddleja davidii Aqueous Extract
Table 2
Effect of plant aqueous extract on the expression of genes related to inflammatory mediators and proinflammatory cytokines in C. acnes-treated HaCaT cells (unit: %).
Herb
iNOS
COX-2
TNF-α
IL-1β
IL-6
IL-8
Akebia quinata
160
218
81
123
131
87
Angelica japonica A. Gray
67
26
58
65
38
87
Artemisia campestris
38
53
44
73
126
105
Buddleja davidii
41
57
29
32
21
35
Ceramium kondoi Yendo
173
148
115
151
117
95
Chelidonium majus L. var. asiaticum Ohwi
61
54
90
173
112
121
Elaeagnus glabra
50
48
114
211
180
183
Fallopia japonica (Houtt.) Ronse Decr.
167
238
72
87
109
114
Hydrangea macrophylla
120
106
18
22
97
25
Hydrangea serrate
178
116
86
111
132
161
Hydrangea serrata Seringe
110
90
75
66
83
66
Illicium verum
16
73
31
46
61
44
Platycladus orientalis
156
114
31
122
15
182
Pyllacantha fibrosa
25
77
69
62
36
69
Rubus coreanus
60
58
95
113
145
179
Sapindus mukorossi
102
99
60
169
127
107
Control 1: HaCaT with C. acnes-free and without plants aqueous extract. Control 2: HaCaT with C. acnes and without plant aqueous extract (increasing 100% compared with control 1).
