Research Article
Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene
Table 6
Predicted ADMET properties of major T. catappa aqueous leaf extract phytoconstituents and standard diabetic drugs.
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mg/day, HIA: human intestinal absorption, BBB: blood-brain barrier permeation, Pgp-S: P-glycoprotein substrate, Pgp-I: P-glycoprotein inhibitor, LV: Lipinski violation, VV: Veber violation, EV: Egan violation, B: bioavailability, SA: synthetic accessibility, MRTD: maximum recommended therapeutic dose, HLM: human liver microsomal stability, hERG: human ether-à-go-go-related gene, DILI: drug-induced liver injury, HepG2: HepG2 cytotoxicity, MMP: mitochondrial membrane potential. |