Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model

Figure 10

Summary of pathways implicated in the triple coculture experiment as proposed by literature. The purple arrows indicate the changes occurring as a result of RA patient serum-conditioned media. The green arrows indicated the changes occurring as a result of BMP-7 treatment. BMP-7 = bone morphogenetic protein-7; HGF = hepatocyte growth factor; TGF-β = transforming growth factor-β.